The increasing interest of improving patients outcome in terms of survival and response, seems to underlie the lack of attention to the anti-emetic prophylaxis. Many clinicians maybe believe that CINV constitutes a “minimal” price to pay for survival gain. On the other hand, patients frequently do not discuss chemotherapy-related side effects, since they may believe that these effects are an ex...

In the physical sciences a rigorous theory is a hierarchy of descriptions in which causal relationships between many general types of entity at a phenomenological level can be derived from causal relationships between smaller numbers of simpler entities at more detailed levels. The hierarchy of descriptions resembles the modular hierarchy created in electronic systems in order to be able to mod...

This paper develops the notion of temporal abstraction, used originally for the automatic understanding of looping constructs, to account for a class of recursive programs involving side effects upon a relational data base. The programs may involve compositions of several side effects, and these side effects can occur either during descent or upon ascent from recursive calls.

Introduction GMC Guidelines illustrate the importance of documenting key elements of a consultation such as side effects of medication and an assessment of patient’s capacity. Not documenting this information makes a clinician liable if complications arise as there is no evidence of a discussion taking place. Do clinicians document this important information? Our aim was to look for evidence of...

With scientific advances in medical sciences over the years many new diagnostic as well as treatment modalities are developed with many patients getting quality of life which was not available before. On the other hand it is also observed that with advances in medical sciences the patient care is becoming more and more specialized and many new super specialty services coming up. As result of su...

The new technologies that the world races to embrace affect every facet of our lives. But not every new technology makes our lives better. Choosing the wrong technology for an application often has serious and costly side effects. In this document I will examine some of the side effects which have been introduced as computers have become more ubiquitous in educational settings. I will then prop...

162 Journal of Family Planning and Reproductive Health Care 2003: 29(3) Background Inevitably there are limited long-term safety data for any new contraceptive method. Detailed scientific studies, performed in a small number of women, provide evidence on mode of action. Larger clinical trials examine efficacy, side effects and acceptability. The number of women-years of exposure is less than fo...

Objectives: Patients with schizophrenia taking firstor second-generation antipsychotic drugs may switch to treatment with Aripiprazole due to side effects. This atypical antipsychotic launched in Europe in 2004, and has a better reported safety profile. However, patients also discontinue Aripiprazole, despite the lack of a comparable alternative antipsychotic. As very few data are available in ...

PM has the potential to optimize the delivery and dosing of treatments so patients can receive the most benefit at the least amount of risk and harm, eliminating both the unnecessary side effects of toxic treatments such as chemotherapy and the delays associated with the “trial-and-error” process that many patients endure to obtain the correct diagnosis and treatment for their condition. And wh...

“The most fruitful basis for the discovery of a new drug is to start with an old one” is a citation from Sir James Black’s Nobel laureate (1988). The background of this statement lies in the fact that most drugs are able to bind to multiple protein targets in the human body, this is known as polypharmacology. This behaviour can lead to unwanted side effects, and innovative research to avoid suc...