The course of radiation-induced sialadenitis in 58 cases in the salivary gland registry (Institute for Pathology of the University of Hamburg 1965-1987) was subjected to pathohistological and immunohistochemical analysis. The pathohistological changes may be classified by severity into 3 stages. Stage I is characterized by mild inflammatory interstitial changes and moderate atrophy of individua...

INTRODUCTION Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibro-inflammatory condition. Forty-two cases with immunoglobulin G4-related sialadenitis (IgG4-RS) confirmed by histopathological and immunohistochemical assessment were studied to clarify the clinicopathologic characteristics of the salivary glands involved in IgG4-RS, especially the relationship between the histop...

The purpose of the present study was to investigate the possibility of experimental induction of sialadenitis in rats by heterologous anti-salivary gland antibodies. Two fractiens (Fractions I and II) were separated from rat submaxillary gland by SephadexG 200 gel-filtration, and then rabbits were immunized with each fraction. Although cross-reactivitv of anti-Frl antiscrum obtained from the ra...