Telomeres are specialized DNA-protein structures located at the ends of eukaryotic chromosomes whose length is progressively reduced in most somatic cells during ageing. Over the past decade, emerging evidence has shown that the telomeres are essential regulators of cellular life span and chromosome integrity in a dynamic fashion. By inducing genomic instability, replicative senescence and apop...

BACKGROUND Conventional cardiac imaging methods do not depict true segmental myocardial shortening, since they cannot determine segment length between fixed points in the myocardium. METHODS AND RESULTS We used electrocardiographically gated magnetic resonance imaging with spatial modulation of magnetization to noninvasively "tag" the myocardium with dark stripes at uniform 7-mm intervals cen...

BACKGROUND There are no established guidelines on the age or the severity of deformity for which an ulna shortening osteotomy or ulna epiphysiodesis should be performed in children and adolescents with Madelung deformity. The purpose of this study was to identify radiographic criteria associated with the eventual performance for an ulna shortening procedure in this patient population. METHODS...

Abstract Croissants are made using solid fats that predominantly contain saturated fatty acids and trans acids. In this study, an oleogel consisting of sunflower oil structured with hydroxypropyl methylcellulose was used as a conventional fat replacer in puff pastry thus improving its nutritional profile. Oleogel (OG)-shortening (SH) blends were prepared for partial (50, 60, 70%) full shortenin...

The influence of series elastic structures on the dynamics of the contractile machinery was examined in the gastrocnemius medialis (GM) of five male Wistar rats, with respect to enhancement of work of a muscle-tendon complex after active stretch. Imposed isotonic and isokinetic contractions were preceded by either an isometric phase (PI) or an active stretch (PS). The effects of fibre length di...