We formulate a microscopic, force-level, activated dynamics-based statistical-mechanical theory for the continuous startup nonlinear shear-rheology of ultra-dense glass-forming hard-sphere fluids and colloidal suspensions in context ECNLE approach. Activated structural relaxation is described as coupled local-nonlocal event involving caging longer-range collective elasticity which controls char...

The c-fos protein belongs to a family of transcriptional cofactors that can complex with proteins of the Jun family and activate mRNA transcription from gene promoters containing an activator protein 1 (AP-1) binding element. The shear stress inducibility of the c-fos protein was studied in human and animal cell lines of vastly different origins. Primary human umbilical vein endothelial cells (...

OBJECTIVES We aimed to investigate the effect of parecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on in vivo shear stress-induced platelet aggregation in a rat model of arterial bypass with focal narrowing. BACKGROUND Long-term use of COX-2 inhibitors is associated with increased incidence of adverse cardiovascular events, especially in patients with a history of cardiovascular dise...

BACKGROUND Hemorrhage is a major complication of trauma and often becomes more severe in hypothermic patients. Although it has been known that platelets are activated in the cold, studies have been focused on platelet behavior at 4 degrees C, which is far below temperatures encountered in hypothermic trauma patients. In contrast, how platelets function at temperatures that are commonly found in...

We investigate the steady and transient shear and extensional rheological properties of a series of model hydrophobically modified ethoxylate-urethane (HEUR) polymers with varying degrees of hydrophobicity. A new nonlinear two-species network model for these telechelic polymers is described which incorporates appropriate molecular mechanisms for the creation and destruction of elastically-activ...

The present paper is dedicated to the modeling of non-linear behavior reinforced concrete structures subject transverse shear or torsion under monotonic and cyclic loading. fiber beam element approach has been proved be an interesting strategy, but needs improved for effects. This can achieved by enhancing cross-section kinematics with a warping displacement field. field must free from rigid bo...

Microwave heating potentially reinforces the muddy intercalation to eliminate slope failure. Montmorillonite has worst water resistance among components, which is a primary facet of inducing This study investigates mechanism shear strength and stability enhancement montmorillonite heated by microwave oven muffle furnace from room temperature 800 °C. Results show that mineralogical evolution can...