Conditioning of endothelial cells by shear stress suppresses their response to inflammatory cytokines. We questioned whether signalling through different integrin-matrix interactions, previously associated with the pathogenic effects of disturbed flow, supported the anti-inflammatory action of steady shear. Primary human endothelial cells were cultured on different substrates and exposed to she...

Endothelial cells are subjected to biochemical and mechanical stimuli, which regulate their angiogenic potential. We determined the synergistic effects of sphingosine-1-phosphate (S1P) and fluid wall shear stress (WSS) on a previously established model of human umbilical vein endothelial cell invasion into three-dimensional collagen matrices. Collagen matrices were incorporated into a parallel-...

Large-eddy simulation (LES) is used to investigate turbulence in a marginally-unstable stratified shear layer motivated by the observation of deep-cycle turbulence in the upper Equatorial Undercurrents. The initial condition consists of uniform shear and stratification profiles, and a constant gradient Richardson number Rig = 0.25. A constant wind stress forces turbulence in the upper surface l...

Colloidal gels are formed by the aggregation of Brownian particles into clusters that are, in turn, part a space-spanning percolated network. In practice, microstructure colloidal gels, which dictates their mechanical properties, strongly depends on particle concentration and nature interactions. Yet another critical control parameter is shear history experienced sample, controls size density c...