Androgens are widely acknowledged to be central to the pathogenesis of benign prostatic hypertrophy (BPH). However, BPH increases in prevalence as men age, at precisely the stage of life when plasma androgens are decreasing. The decrease in total plasma androgens is amplified by an age-related increase in plasma sex hormone-binding globulin (SHBG) that results in a relatively greater decrease i...

The prostate develops in the urogenital sinus (UGS) under the influence of androgens. Whilst free androgens can enter the cell to activate the androgen receptor and induce prostate development, approximately 98.5% of androgens in plasma are bound to binding proteins such as sex hormone binding globulin (SHBG). There is increasing evidence that an alternative pathway for androgens to enter targe...

Sex hormones play a central role in the development of breast cancer. Sex hormone-binding globulin (SHBG) modulates the bioavailability of circulating sex hormones and regulates their signaling system in the breast tissue. We evaluated the association of a common functional polymorphism (Asp327Asn) in the SHBG gene with breast cancer risk in a population-based case-control study (1,106 cases an...

OBJECTIVE Lower levels of sex hormone-binding globulin (SHBG) have been associated with increased risk of diabetes among postmenopausal women; however, it is unclear whether they are associated with glucose intolerance in younger women. We examined whether SHBG concentrations, measured before pregnancy, are associated with risk of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHO...

normal 0 false false false en-us x-none ar-sa background: the objective of this study was to investigate whether the sex hormone binding globulin (shbg) levels before conception are predictive of gestational diabetes mellitus (gdm) in women with polycystic ovarian syndrome (pcos). materials and methods: a total of 180 women with pcos were enrolled and followed up during pregnancy. diagnosis of ...

M en with obesity, the metabolic syndrome, and type 2 diabetes have low total and free testosterone and low sex hormone–binding globulin (SHBG). Conversely, the presence of low testosterone and/or SHBG predicts the development of metabolic syndrome and type 2 diabetes. Visceral adiposity present in men with low testosterone, the metabolic syndrome, and/or type 2 diabetes acts through proinflamm...

Background: Sex hormone-binding globulin (SHBG) regulates the levels of free sex hormones by sequestering circulating sex hormones and participates in some of the biological actions of sex hormones by mediating cellular uptake. Low circulating levels of sex hormone–binding globulin are a strong predictor of the risk of type 2 diabetes in women and men. However, it has been difficult to determin...

In their research article published in the September 9, 2005 issue of Cell, Hammes et al. (2005) investigated the role of megalin (an endocytic receptor in a variety of tissues) and SHBG (sex hormone binding globulin) on the cellular uptake of sex steroid hormones in mice. In plasma, androgens and estrogens can circulate bound tightly to SHBG, bound loosely to albumin, unbound, or free. Althoug...

OBJECTIVE The association between total testosterone and metabolic syndrome has prompted speculation that low testosterone contributes to the pathophysiology of metabolic syndrome in men. We determined whether testosterone or sex hormone-binding globulin (SHBG) is independently associated with the risk of metabolic syndrome. RESEARCH DESIGN AND METHODS Cross-sectional relationships of hormone...