Protrusion of the leading edge of migrating epithelial cells requires precise regulation of two actin filament (F-actin) networks, the lamellipodium and the lamella. Cofilin is a downstream target of Rho GTPase signaling that promotes F-actin cycling through its F-actin-nucleating, -severing, and -depolymerizing activity. However, its function in modulating lamellipodium and lamella dynamics, a...

We develop a mathematical model that describes key details of actin dynamics in protrusion associated with cell motility. The model is based on the dendritic-nucleation hypothesis for lamellipodial protrusion in nonmuscle cells such as keratocytes. We consider a set of partial differential equations for diffusion and reactions of sequestered actin complexes, nucleation, and growth by polymeriza...

Femoroacetabular impingement (FAI) is a condition characterized by the impingement of the femur and acetabulum. In Japan, this disorder has become recognized gradually. Here we report a rare case of surgically treated FAI, associated with an osseous protrusion on the acetabulum of a 30-year-old female. Plain computed tomography (CT) and reconstructive 3D-CT images clearly demonstrated an antero...

La protrusion pyramidale périanale est une entité d'individualisation récente, assez rare, touchant presque exclusivement le sexe féminin souvent en bas âge, d'origine congénitale, fonctionnelle ou associée au lichen scléroatrophique. Dans la première forme, la lésion serait due à une faiblesse constitutionnelle de la paroi périnéale, notamment du raphé médian, ou serait secondaire à une malfor...

L-shaped concrete-filled steel tubular (CFST) columns represent a valuable structural element with an cross-section, primarily employed in the corner of framed structures. These offer several advantages, including space efficiency by avoiding column protrusion, robust mechanical properties, high load-bearing capacity, ductility, and efficient utilization internal building space. This article pr...

BACKGROUND The relative merits of round versus naturally shaped breast implants continue to be a subject of debate. OBJECTIVE The results of augmentations with McGhan Style 110 round textured noncohesive-gel-filled implants were compared with those using McGhan Style 410 FM naturally shaped, textured cohesive-gel-filled implants in 2 similar groups of patients. METHODS Patients in each impl...

Both free and cracked surfaces of the saccus vasculosus in adult rainbow trout (Salmo gairdneri) have been investigated by scanning electron microscopy (SEM). The saccus vasculosus is the rich-folded epithelium composed of highly specialized coronet cells, supporting cells, and presumable liquor-contact neurons. The coronet cells are characterized by both numerous specialized cilia, so-called "...

1 ABSTRACT The continuous casting process is a widely used technique in modern steel plants. However, it is a complicated process that is not well understood. The objective of this research is to model the porosity and macrosegregation due to shrinkage related effects and solid deformation in the continuous casting of steel. Solid phase movements due to bulging and variable roll gap are modeled...

The aim of this investigation was to analyse and compare the reproducibility of manual cephalometric tracings with on-screen digitization using a soft tissue analysis. A random sample of 20 lateral cephalometric radiographs, in the natural head posture, was selected. On-screen digitization using Viewbox 3.1.1.9 cephalometric software and manual tracing on a 1:1 printout of the image was carried...

Carotid artery stenting (CAS) is one of the treatments for carotid stenosis; however, it associated with risk postoperative embolism due to in-stent plaque protrusion. CASPER Rx (Terumo, Co.) stent expected prevent protrusion because double-layered structure. Double-layer segment required be deployed over during placement; real-time understanding position difficult. Percutaneous ultrasound exam...