Department of Biochemistry, Faculty of Pharmacy, October 6th University, October 6th city, Egypt E-mail : [email protected] ABSTRACT-: This study was carried out to evaluate the structure activity relationship and biochemical effects of some novel of anti-inflammatory triazoloquinazolines and triazinoquinazolines containing sulfacetamide moiety. Some of the newly synthesized compoun...

By GORDON B. MAGILL, FELIX WROBLEWSKL AND JOHN S. LADUE D URING the initial studies on serum lactic dehydrogenase ( SLD ) and serum transaminase ( SGOT ) in relation to myocardial infarction, high levels of SLD activity were noted! in patients with acute stem cell leukemia and with chronic myelogenous leukemia as well as in patients with widespread metastatic carcinoma.1 A preliminary report by...

Diabetes mellitus (DM) is commonly associated with thyroid dysfunction. The aim of the present study was to evaluate the prevalence of thyroid dysfunction in subjects with type 2 diabetes and the effect of type 2 diabetes mellitus on other bio-chemical variables. In the present study 80 type 2 diabetic subjects and 80 healthy non diabetic subjects were investigated for total triidothyronine (T3...

Aerial parts of Echinops echinatus (Family: Asteraceae) were subjected to in vivo hepatoprotective study in order to validate its traditional use in hepatobiliary disorders, by native people of Cholistan Desert, Pakistan. Hepatoprotective effects of pre-treatment with aerial parts (ethanolic extract) of E. echinatus (EE), (500 and 750 mg/kg/day, p.o., for 7 days) against CCl4 (0.75 ml/kg., s/c....

The GeMSAEC fast analyzer provides the clinical chemistry laboratory with an analytical instrument that can be used to perform large numbers of kinetic enzyme analyses. Precise enzyme-rate analyses can be done routinely, on a large scale, and at a decreased cost per test. Improved precision in analyses of enzymes should provide more reliable data because analytical variation is lessened. We hav...

Hyperlipidemia is a common metabolic disorder contributing to morbidities and mortalities due to cardiovascular and cerebrovascular diseases. Conventional antihyperlipidemic drugs have limited efficacies and important side effects, so that alternative lipid lowering agents are needed. Salvia officinalis L. (sage) leaves have PPAR γ agonistic, pancreatic lipase and lipid absorption inhibitory, a...

Methanolic extract of Luffa cylindrica (L.) M. J. Roem. leaves (MELC) was evaluated for its hepatoprotective potential against paracetamol intoxicated wistar rats. Administration of MELC and standard drug silymarin showed significant (P <0.05) hepatoprotective protection in experimental animals. The study was conducted by estimating serum enzyme activities of serum glutamate oxaloacatate transa...

Isoproterenol, a catecholamine acting as a β adrenergic agonist, is commonly used to establish myocardial infarction (MI) in animal models for drug development. Although cheaper than isoproterenol, salbutamol is another type of catecholamine, may be potentially and equally used for the onset of MI in animal model. However the concentrations of salbutamol for inducing MI need to be optimized and...

It is difficult to make a retrospective diagnosis of perinatal asphyxia in symptomatic neonates delivered non-institutionally. We studied serum creatine kinase muscle-brain fraction (CK-MB), lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (SGOT) and glutamic pyruvate transaminase (SGPT) for differentiating asphyxiated (n=25) from non-asphyxiated (n=20) neonates who present with n...

OBJECTIVE Determine the risk factors and pregnancy outcomes of eclampsia in our institution. MATERIAL AND METHOD The authors conducted a case-control study of 80 Thai pregnant women with eclampsia and 240 controls with mild preeclampsia who delivered at King Chulalongkorn Memorial Hospital, Bangkok, Thailand between 1995 and 2011. Information was abstracted on established and hypothesized ris...