OBJECTIVE Meaningful exchange of information is a fundamental challenge in collaborative biomedical research. To help address this, the authors developed the Life Sciences Domain Analysis Model (LS DAM), an information model that provides a framework for communication among domain experts and technical teams developing information systems to support biomedical research. The LS DAM is harmonized...

Although the benefits of dam construction are numerous, particularly in the context of climate change and growing global demand for electricity, recent experience has shown that many dams have serious negative environmental, human, and political consequences. Despite an extensive literature documenting the benefits and costs of dams from a single disciplinary perspective, few studies have simul...

DNA adenine methyltransferase (Dam) is widespread and conserved among the γ-proteobacteria. Methylation of the Ade in GATC sequences regulates diverse bacterial cell functions, including gene expression, mismatch repair and chromosome replication. Dam also controls virulence in many pathogenic Gram-negative bacteria. An unexplained and perplexing observation about Escherichia coli Dam (EcoDam) ...

A dam ant colony optimization (D-ACO) analysis of the overall stability of high arch dams on complicated foundations is presented in this paper. A modified ant colony optimization (ACO) model is proposed for obtaining dam concrete and rock mechanical parameters. A typical dam parameter feedback problem is proposed for nonlinear back-analysis numerical model based on field monitoring deformation...

DNA methylation by the DNA adenine methyltransferase (Dam) interferes with the coordinated expression of virulence functions in an increasing number of pathogens. While analyzing the effect of Dam on the virulence of the human pathogen Yersinia enterocolitica, we observed type III secretion of Yop effector proteins under nonpermissive conditions. Dam alters the Ca(2+) regulation of Yop secretio...

BACKGROUND DNA adenine methylation plays an important role in several critical bacterial processes including mismatch repair, the timing of DNA replication and the transcriptional control of gene expression. The dependence of bacterial virulence on DNA adenine methyltransferase (Dam) has led to the proposal that selective Dam inhibitors might function as broad spectrum antibiotics. METHODOLOG...

This paper applies the tool of social impact assessment (SIA) to understand the effects of large dam projects on human communities. We draw upon data from two recent SIA projects: the Lesotho Highlands Water Project in Southern Africa, and the Manwan Dam, located on the upper Mekong River in southwestern China. These two cases allow us to examine the social impacts of large dam projects through...

At present, more and more attentions have been paid to dam risk management around the world. In order to deal with the fuzziness and randomness of dam failure, the cloud model was introduced into the risk assessment of dam failure, which was combined with Analytic Hierarchy Process(AHP) method and fuzzy theory, and then the multilevel fuzzy comprehensive assessment of dam failure risk was reali...

Today Environmental Impact Assessment (EIA) is known as one of the most important tools for decision makers in the construction of civil and industrial projects towards sustainable development. In the past, projects were evaluated based on cost and benefit analysis regardless of the physical and biological environmental effects and its socio-economical impacts. According to the Department of En...

The temporal migration patterns of European glass eel Anguilla anguilla at the Couesnon estuarine dam (Mont-Saint-Michel Bay, France) were examined in winter and spring 2004 and 2005. The dam which is located close to the river mouth constitutes a major obstacle for upstreammigrating glass eels. The migration was observed at different temporal scales, from within individual tides to complete ti...