Hemophilia A is a common X chromosome-linked genetic bleeding disorder caused by abnormalities in the coagulation factor VIII gene (F8). Hemophilia A patients suffer from a bleeding diathesis, such as life-threatening bleeding in the brain and harmful bleeding in joints and muscles. Because it could potentially be cured by gene therapy, subhuman animal models have been sought. Current mouse hem...

The ability of factor VIIa to initiate thrombin generation and clot formation in blood from healthy donors, blood from patients with hemophilia A, and in anti–factor IX antibody–induced (“acquired”) hemophilia B blood was investigated. In normal blood, both factor VIIa–tissue factor (TF) complex and factor VIIa alone initiated thrombin generation. The efficiency of factor VIIa was about 0.0001 ...

Background: Together hemophilia A and B are categorized through spontaneous indoors bleeding excessive later on accidents or surgery. The biggest common places for into joints much less commonly in muscle tissues organs such as the talent kidneys. Objective(s): aim of study is to assess knowledge parents regarding health preventive measures self-care children. Method: a descriptive design carri...

BACKGROUND Acquired hemophilia type A (AHA) is a rare and deadly condition. It caused by autoantibodies to factor VIII. diagnostic therapeutic challenge with the potential development of complications, which can put at risk life person presenting it. CASE REPORTS We present two cases patients that have bleeding disorders, diagnosis AHA diagnosed activated partial thromboplastin time prolonged i...

premenstrual syndrome is a common disorder experienced by up to 50% of women during reproductive age. the prevalence of severe form of pms (pmdd) is 3% to 8 %. psychiatric disorders in pms patients have resulted in significant morbidity and in some cases caused resistance to the treatment process.390 participants (264 with pms/pmdd, and 126 healthy students of university of guilan) who complete...

background: considering the increasing number of patients with hemophilia and infrastructure requirements for a comprehensive approach, development of a recombinant factor has become a milestone. the objective of this study was to assess the safety, efficacy and non inferiority of safacto (recombinant factor viii) compared with plasma-derived factor in the treatment of hemophilia a. methods: 10 ...

OBJECTIVE Hemophilia B is caused by coagulation defects in the factor IX gene located in Xq27.1 on the X chromosome. A wide range of mutations, showing extensive molecular heterogeneity, have been described in hemophilia B patients. Our study was aimed at genetic analysis and prenatal diagnosis of hemophilia B in order to further elucidate the pathogenesis of the hemophilia B pedigree in China....

Hemophilia A and B are X-chromosome linked bleeding disorders caused by deficiency of the respective coagulation factor VIII and IX. Affected individuals develop a variable phenotype of hemorrhage caused by a broad range of mutations within the Factor VIII or Factor IX gene. Here, were report the results of the molecular diagnosis in a five Costa Rican families affected with Hemophilia. Methods...

the aim of this study was to investigate c-reactive protein (crp) level in preeclampsia (pe) and its association with the severity of the disease. this cross-sectional study included 43 women with mild pe, 43 women with severe pe, and 43 healthy pregnant. they were selected in the third trimester of pregnancy in the afzalipour hospital, kerman, iran, from march 2006 to march 2007. mean diastoli...