The kidney has a vital role in magnesium homeostasis and, although the renal handling of magnesium is highly adaptable, this ability deteriorates when renal function declines significantly. In moderate chronic kidney disease (CKD), increases in the fractional excretion of magnesium largely compensate for the loss of glomerular filtration rate to maintain normal serum magnesium levels. However, ...

OBJECTIVE A study with human volunteers was conducted to ascertain whether a low intake of copper (Cu) would exacerbate the response to a deficient intake of magnesium (Mg). METHODS Nineteen postmenopausal women, age 47 to 78 y, completed a metabolic unit study as designed. For 162 d, nine women were fed a diet containing 1.0 mg of Cu/2000 kcal and 10 women were fed 3.0 mg of Cu/2000 kcal. Di...

An automated method for magnesium determination in serum is described using conventional AutoAnalyser equipment. The method gives results comparable with those obtained by the flame photometer. The method may prove particularly useful with subnormal serum magnesium levels.

Magnesium, an essential mineral for human health, plays a pivotal role in the cardiovascular system. Epidemiological studies in the general population have found an association between lower dietary magnesium intake and an elevated risk of cardiovascular events. In addition, magnesium supplementation was shown to improve blood pressure control, insulin sensitivity, and endothelial function. The...

BACKGROUND Sevelamer has been associated with less progression of vascular calcifications. This effect could be due to a reduction in serum phosphate levels but also to other additive effects. Magnesium has been also shown to prevent vascular calcification but the effect of sevelamer on serum magnesium levels has not been thoroughly evaluated. Our aim was to analyze whether the use of sevelamer...

The concentration of free, ionized magnesium in undiluted blood serum can be determined potentiometrically with a new magnesium-selective carrier in polymeric membrane electrodes (by weight 66% plasticizer, approximately 33% polyvinyl chloride and approximately 1% ionophore). However, discrimination of calcium by the new ionophore-added membrane is not sufficient to keep calcium interference to...

Introduction Renal replacement therapy is a general term applied for several techniques which are used in the treatment of patients with end-stage renal failure. It includes different methods such as hemodialysis, peritoneal dialysis, and renal allograft transplantation (1,2). The efficacy of peritoneal dialysis as a method of renal replacement therapy has been proven. The purpose of dialysis i...

CUTE AND chronic alcoholism are the most common A settings for hypomagnesemia in everyday clinical practice.' In almost all studies addressing this issue, the total serum magnesium concentration was although there are limitations on its use in evaluating total body magnesium stores.' Recently, commercially available instruments with new ion-selective electrodes for ionized magnesium, the biolog...

BACKGROUND Because magnesium blocks the N-methyl-D-aspartate receptor and its associated ion channels, it can prevent central sensitization caused by peripheral nociceptive stimulation. However, transport of magnesium from blood to cerebrospinal fluid (CSF) across the blood-brain barrier is limited in normal humans. The current study was designed to evaluate whether perioperative intravenous ma...