The aim of the research was to determine differences in IL-1ß, IL-2, IL-4, IL-10, IL-17, INF-γ, TNF-α and IL-1ra blood concentrations pregnant non-pregnant healthy mares. mares were divided into two groups: (n = 18; age 6.11 ± 2.25 years); 6; 5.67 1.75 years). Blood samples collected from all 24) three times every month, then group subgroups based on pregnancy (1st 6)—6th, 7th, 8th; 2nd 6)—7th,...

Objective. The aim of this study was to investigate the changes of regulatory T cells (Treg), interleukin-6 (IL-6), IL-10, transforming growth factor-β (TGF-β), and tumor necrosis factor-alpha (TNF-α) in patients with type 2 diabetes mellitus (T2DM). Methods. We performed a comprehensive search up to July 2016 for all clinical studies about the changes of Treg, IL-6, IL-10, IL-17, TGF-β, and TN...

background: daunorubicin‑induced acute cardiotoxicity caused by oxidative stress and free radical formation. pomegranate possessed a significant in vitro free radical scavenging activity. therefore, the aim of this study was estimations of the role of pomegranate effects in daunorubicin‑induced cardiotoxicity. methods: a total of 21 sprague male rats were allocated into three groups, seven anim...

Interleukin (IL) 17 is produced by T-helper (Th) 17 with a vigorous effect on cells of the immune system playing important roles in pathogenesis of immune-mediated diseases, including autoimmune disorders and cancers. Therefore, the aim of current study was to determine the serum levels of IL-6, IL-17, and transforming growth factor beta (TGF-β) in Iranian bladder cancer patients, and to correl...

Objective To investigate serum protein expression in participants with psoriatic arthritis (PsA) and changes after guselkumab treatment. Methods Participants PsA were treated or placebo the DISCOVER-1 DISCOVER-2 studies. Serum levels of acute phase reactants C reactive (CRP) amyloid A (SAA) inflammatory cytokines/chemokines measured at weeks 0, 4 24 300 study 34 healthy controls (HCs). The PSUM...

BACKGROUND Up-regulation of interleukin 17 (IL-17) family cytokines and acute phase response have been observed in patients with chronic spontaneous urticaria (CSU). It has been demonstrated that IL-17 stimulates C-reactive protein (CRP) expression. AIM To determine relationship between circulating concentrations of IL-17 and CRP in CSU. METHODS Concentrations of IL-17 in plasma and CRP in ...

Objectives Inflammatory bowel disease (IBD) and spondyloarthritis (SpA) have some overlapping clinical features, i.e. gut and joint inflammation. Cytokines of interleukin 17(IL-17)/IL-23 axis play a pathogenic role in both diseases. Integrins (ITGs) regulate migration of immune cells to inflamed tissues (ITGβ7 into gut, ITGβ2 into gut and also to other tissues). In this study, we search for dif...

Objective(s): Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed. In the present experiment, the effect of vitamin D3 on the expression of...

BACKGROUND Tumor growth in multiple myeloma (MM) is regulated by the cytokine networks which are produced by myeloma cells and the microenvironment of the bone marrow. Interleukin-17 (IL-17) is implicated in the increased angiogenesis in the bone marrow of MM. Recent studies reported elevated levels of interleukin 17A (IL-17A) in the sera of patients with advanced stages according to Durie-Salm...

BACKGROUND Tumor necrosis factor-alpha (TNF alpha), which we and others have shown to be elevated in patients with severe congestive heart failure (CHF), is involved in the regulation of nitric oxide metabolism. Whether increased concentrations of TNF alpha affect nitric oxide-mediated vasodilation in patients with CHF has not been studied previously. METHODS AND RESULTS Serum concentrations ...