Serotonergic medications are used for the prevention and treatment of depression during pregnancy. Selective serotonin reuptake inhibitors serotonin-norepinephrine (SNRIs) can cause poor neonatal adaptation, which has been attributed to withdrawal versus toxicity. Bupropion, a norepinephrine-dopamine inhibitor, is often as an adjunctive agent selective or SNRIs refractory depression. Quetiapine...

BACKGROUND The selective serotonin reuptake inhibitors are major drugs used in psychiatry today. While serotonin syndrome has become more frequent in an overdose situation and when an interacting drug is given, the toxicity of SSIRs is less than that of most other psychiatric drugs. Although the characteristics of toxicity are defined, it seems that physicians are not aware of the phenomenon. ...

Deficiency of tryptophan with elevated serum serotonin and liver dysfunction are the prerequisites for the experimental production of cardiac lesions in the guinea pig model of carcinoid syndrome. To apply the above principles in human subjects with carcinoid disease, various indole markers were compared in patients with or without heart involvement, to a group of normal subjects. In the presen...

A broader palette of safe and better-tolerated agents is available for treating people suffering from chronic schizophrenia, depressive disorders, anxiety disorder, autism spectrum disorders. However, current medical treatments are still only partially effective, and highly-prevalent psychiatric disorders continue to represent a huge personal and socio-economic burden. Most pharmacological agen...

The serotonin syndrome, which is characterized by psychiatric, autonomic nervous and neurological symptoms, is considered to be caused by excessive stimulation of the 5-HT1A and 5-HT2 receptors in the gray matter and spinal cord of the central nervous system, after the start of dosing or increase of the dose of a serotoninergic drug. There have been hardly any reports of induction of serotonin ...

Serotonin is an important monoamine to the anesthetist for many reasons. An increase or decrease of serotonin concentration in the brain changes the minimum alveolar concentration (MAC) of inhalational anesthetics; precipitous release systemically, as in carcinoid syndrome, produces devastating effects on the cardiovascular and pulmonary systems. Serotonin is ubiquitous and has many roles in th...