objective (s): there is corroborating evidence to substantiate redox imbalance and oxidative stress in sepsis that finally leads to organ damage or even death. gamma oryzanol (go) is one of the major bioactive components in rice bran has been considered to function as an antioxidant. the present study was carried out to evaluate the antioxidant activity of gamma oryzanol in vitro and its effica...

background: the appropriateness of using serum levels of procalcotonin (pct) for early diagnosis of newborn sepsis is still controversial. therefore, the objective of the present study was to compare the usefulness of pct with those of serum levels of c-reactive protein (crp) and white blood cell (wbc) counts in the diagnosis and response to treatment of neonatal sepsis.   methods: a total of 4...

Despite considerable medical advances, sepsis is common and associated with high morbidity and mortality rates [1,2]. In 1991, the Task Force in the First International Consensus Conference used expert opinion to generate the then-current definitions of sepsis (First International Consensus Conference Definitions for Sepsis and Septic Shock [Sepsis-1]) based on the presence of systematic inflam...

The aim. This review provides a meta-analysis of current guidelines on nutrition in critically ill patients, including SCCM–ASPEN (2017), SSC (2012, 2021), ESPNIC (2020), and (2020) pediatric sepsis guidelines. While the guidance complements existing ASPEN (2017) for critical paediatrics, Children's did not find sufficient direct evidence to develop strong nutritional recommendations children w...

OBJECTIVE Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase. Majority of sepsis-mortality occurs during the late sepsis; no therapies exist to treat late sepsis. In lean mice, we have shown that sirtuins (SIRTs) modulate this transition. Here, we investigated the role of sirtuins, especially ...

a preterm female baby with birth weight of 1.5kg was referred to our hospital on day 6 for difficulty in breathing. baby was admitted at birth for respiratory distress and feed intolerance to other hospital and in view of clinical deterioration baby was referred. baby had thrombocytopenia with platelets counts of 11000/ mm3 and high crp titer. baby had petechial haemorrhagic spots all over the ...

Background Sepsis is common in cirrhosis and often a result of immune dysregulation. Specific stimuli pathways inter-cellular communications between cells sepsis are incompletely understood. Immune cell-derived extracellular vesicles (EV) were studied to understand mechanisms cirrhosis. Methods EV measured patients [Child-Turcotte-Pugh (Child) score A, n = 15; B 16; C 43 Child-C with (n 38)], h...

BACKGROUND Sepsis and severe sepsis are common conditions in hospital settings, and are associated with high rates of morbidity and mortality, but reported incidences vary considerably. In this literature review, we describe the variation in reported population-based incidences of sepsis and severe sepsis. We also examine methodological and demographic differences between studies that may expla...

Sepsis is a systemic inflammatory response syndrome that caused by infection. It one of the most common critical diseases clinically. Although more anti-inflammatory drugs are available, treatment options for sepsis remain limited. The nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome multiprotein complex has been implicated in development and evolution other autoimmune dis...

BACKGROUND Sepsis is the focus of national quality improvement programs and a recent public reporting measure from the Centers for Medicare and Medicaid Services. However, diagnosing sepsis requires interpreting nonspecific signs and can therefore be subjective. We sought to quantify interobserver variability in diagnosing sepsis. METHODS We distributed five case vignettes of patients with su...