We describe two patients with diabetes mellitus and associated neuropathy, who presented with painless foot swelling and no history of trauma. X-Rays revealed recent underlying fractures-in one of a metatarsus, and the other of a proximal phalanx. These were assumed to be 'stress' fractures unassociated with pain because of the severe sensory neuropathy. Though spontaneous fractures in neuropat...

PURPOSE OF REVIEW This article provides a clinical approach to peripheral neuropathy based on anatomic localization and diagnostic testing. RECENT FINDINGS Advances have been made in the evaluation of small fiber neuropathy and in the known genetic causes of neuropathy. SUMMARY History and physical examination remain the most useful tools for evaluating peripheral neuropathy. Characterizati...

There is increasing evidence that monoclonal proteins are implicated in the development of peripheral neuropathy. Approximately ten percent of patients with peripheral neuropathy of unknown cause have a monoclonal protein and this rate is significantly higher than prevalence rates of monoclonal protein in comparable segments of the general population. Extensive clinical, electrophysiological an...

Paraneoplastic polyneuropathies are among the most common distal neurological complications of systemic cancer on the nervous system. All peripheral neuropathy types, such as demyelinating, axonal, motor, sensory, or autonomic, can present in association with cancer and can have a paraneoplastic etiology (1). Classical paraneoplastic peripheral neuropathy is typically a sensory neuropathy with ...

Seventy five patients with chronic idiopathic axonal polyneuropathy (CIAP) were studied for five years. The standardised and quantified neurological examination shows that progression of CIAP is slow, and handicap, if present, is not severe. During the follow up period a definite cause of the neuropathy was found in only four patients (two hereditary motor and sensory neuropathy type 2, one sen...

paclitaxel is a highly effective anticancer agent. it is active against a broad range of cancers that are generally considered refractory to conventional chemotherapy. paclitaxel induces a peripheral neuropathy (pn) that is characterized by sensory symptoms such as numbness and paresthesia in a glove and stocking distribution. pn may be severe and dose limiting at initial doses above 275 mg/m2....

OBJECTIVE To study the nerve conduction velocity in clinically undetectable and detectable peripheral neuropathy in type 2 diabetes mellitus with variable duration. MATERIAL AND METHODS This cross sectional study was conducted in diagnosed type 2 diabetes mellitus patients. They were divided in groups: Group I (n=37) with clinically detectable diabetic peripheral neuropathy of shorter duratio...

Pure trigeminal motor neuropathy is characterized by trigeminal motor weakness without signs of trigeminal sensory or other cranial nerve involvement. We describe a 63-year-old woman with progressive weakness and atrophy of the left masticatory muscles. She had no sensory disturbance. The diagnosis of pure trigeminal motor neuropathy was made on the basis of clinical and electrophysiologic stud...

Objective. Examining the prevalence of laryngeal sensory neuropathy (LSN) in goiter patients versus a control group. Study Design. Cross-sectional study. Methods. 33 Goiter patients were enrolled versus 25 age-matched controls. TSH levels, size of thyroid gland, and presence or absence of thyroid nodules were reported. Subjects were asked about the presence or absence of any of the following sy...

Hereditary sensory neuropathy type I (HSN I) is a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset. The exact prevalence is unknown, but is estimated as very low. Disease onset varies between the 2nd and 5th decade of life. The main clinical featu...