The development of solid-phase peptide synthesis in the early 1960s and recombinant DNA technology in the early 1970s boosted the scientific interest of utilizing proteins and peptides as potential therapeutic agents to battle poorly controlled diseases. While there has been rapid progress in the development and synthesis of new proteins and peptides as potential therapeutic agents, the formula...

This paper describes two types of polymeric micropumps based on the temperature-sensitive hydrogel poly(N-isopropylacrylamide). The gel actuators are realised as photopolymerised patterns and microgels. They are electrothermically controlled by resistive heating elements. The diffusion-based micropump contains a photopatterned monolithic actuator, which is placed within the pump chamber, and pr...

A glucose-sensitive inverse opal hydrogel was synthesized through photopolymerization of 2-hydroxyethyl methacrylate and 3-acrylamidophenylboronic acid within the interstitial space of a dried poly(styrene) colloidal crystal template, followed by template removal. Charged complex formation between the phenylboronic acid functional group and the 1,2-cis-diol glucose resulted in reversible swelli...

BACKGROUND AND THE PURPOSE OF THE STUDY Many drugs which have narrow therapeutic window and are absorbed mainly in stomach have been developed as gastroretentive delivery system. Rosiglitazone maleate, an anti-diabetic, is highly unstable at basic pH and is extensively absorbed from the stomach. Hence there is a need to develop a gastroretentive system. In this study a superporous hydrogel was ...

We have recently reported that retro Michael-type addition reactions can be employed for producing labile chemical linkages with tunable sensitivity to physiologically relevant reducing potentials. We reasoned that such strategies would also be useful in the design of glutathione-sensitive hydrogels for a variety of targeted delivery and tissue engineering applications. In this report, we descr...

Hydrogels are versatile and environmentally sensitive materials having appealing tunable physical-chemical-mechanical properties, similar to those encountered in natural living tissues, which enable their use a wide range of applications, especially the biomedical field. In present study, we investigate temperature-driven responsiveness one class elastomeric gels, namely poly-N-isopropylacrylam...