Background: Busulfan is an alkylating agent, which inhibits cell dividing by sticking to one of the DNA strands. The aim of the present study was establishment and stereological evaluation of testes of azoospermic animal model using busulfan in albino hamster. Materials and Methods: Male adult albino hamsters were randomly assigned into 3 groups. The first group was injected one dose of busulfa...

Environmental stress affects various parts of mammals typically through the circulation of stress hormones. It has been identified as one of the possible reasons for male reproductive difficulties, but the complex mechanisms responsible for stress-induced reproductive suppression are poorly understood. Here, we examined the relationship between chronic environmental stress and hypothalamic kiss...

Formaldehyde (FA) is the leading cause of cellular injury and oxidative damage in testis that is one of the main infertility causes. There has been an increasing evidence of herbal remedies use in male infertility treatment. This assay examines the role of Ficus carica (Fc) leaf extracts in sperm parameters and testis of mice intoxicated with FA. Twenty-five adult male mice were randomly divide...

BACKGROUND It is well known that diabetes mellitus may cause testicular damage. Vascular endothelial growth factor (VEGF) and nerve growth factor beta (NGF-β) are important neurotrophic factors for male reproductive system. OBJECTIVE We aimed to investigate the correlation between testicular damage and testicular VEGF and NGF-β levels in diabetic rats. METHODS Diabetes was induced by strept...

BACKGROUND It is well known that diabetes mellitus is associated with impairment of testicular function. In the present study, we aimed to demonstrate the effect of melatonin on testicular damage in male rats with streptozotocin (STZ)-induced diabetes. METHODS Male Wistar rats were divided into 4 groups: (1) control group, (2) melatonin-treated nondiabetic group, (3) diabetic group and (4) me...

Introduction: Cyclophosphamide (CP) is used for the treatment of various cancers. In spite of its therapeutic importance, a wide range of adverse effects such as reproductive toxicity has been observed following the administration of this drug in human and experimental animals. In the current study, we have investigated the adverse effects of CP on morphology and histology of testis rats. Metho...

Spermatogenesis ranks among the most complex, yet least understood, developmental processes. The physiological principles that control male germ cell development in mammals are notoriously difficult to unravel, given the intricate anatomy and complex endo- and paracrinology of the testis. Accordingly, we lack a conceptual understanding of the basic signaling mechanisms within the testis, which ...