Regulatory T cells have been shown to prevent the development of autoimmune disease, and can modulate immune responses during infections or following tissue transplantation. Recently, the processes by which CD4+CD25+ regulatory T cells are produced during immune repertoire formation have begun to be elucidated. This review focuses on the role of self-peptides in mediating CD4+CD25+ regulatory T...

weakness of research & development strategy for technology transfer management in product design activities is one of the most difficulties for local companies in iran. therefore, this paper trying to present a method to indicting research & development strategy for identifying fit technology with requirements of customer and provide a solution for acquisition of needs technologies of companies...

In recent years several strategies for inferring gene regulatory networks from observed time series data of gene expression have been suggested based on Evolutionary Algorithms. But often only few problem instances are investigated and the proposed strategies are rarely compared to alternative strategies. In this paper we compare Evolution Strategies and Genetic Programming with respect to thei...

More and more works are done on design patterns and aspect-oriented programming. These works mainly propose to use aspect-oriented programming mechanisms to provide new implementations of objectoriented design patterns. This paper illustrates our own approach by presenting an aspect-oriented implementation of the GoF Strategy pattern, and claims implementation is not sufficient: aspect-orientat...

Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-10(IL-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-10 during pregnancy may result in several pathologic conditions such as preterm labor. IL-10 leads to a normal pregna...

background: it seems that the success of vaccination for cancer immunotherapy such as dendritic cell (dc) based cancer vaccine is hindered through a powerful network of immune system suppressive elements in which regulatory t cell is the common factor. foxp3 transcription factor is the most specific marker of regulatory t cells. in different studies, targeting an immune response against regulat...

Exploding growth in computational systems forces us to gradually replace rigid design and control with decentralization and autonomy. Information technologies will progress, instead, by“meta-designing” mechanisms of system selfassembly, self-regulation and evolution. Nature offers a great variety of efficient complex systems, in which numerous small elements form large-scale, adaptive patterns....

Recent research on self-regulated learning has stressed the importance of both motivational and cognitive components of classroom learning. Much of this research has examined these components without consideration of potential contextual differences. Using a within-subject correlational design, the present study assessed mean level differences in students’ task value, self-efficacy, test anxiet...

Manipulation of the immune system to prevent the development of a specific immune response is an ideal strategy to improve outcomes after transplantation. A number of experimental techniques exploiting central and peripheral tolerance mechanisms have demonstrated success, leading to the first early phase clinical trials for tolerance induction. The first major strategy centers on the facilitati...