نتایج جستجو برای: selective cox 2 inhibitors

تعداد نتایج: 2821211  

2002
Roberto Bolli Ken Shinmura Yu-Ting Xuan Xian-Liang Tang Eitaro Kodani Hui Han Yanqing Zhu

Cyclooxygenase-2 (COX-2) is known to mediate the cardioprotective effects of the late phase of ischemic preconditioning (PC); however, the signaling pathways involved in COX-2 induction following ischemic PC are unknown. In addition, although inducible nitric oxide synthase (iNOS) has been identified as a co-mediator of late PC together with COX-2, the interaction between iNOS and COX-2 in the ...

Journal: :The Journal of pharmacology and experimental therapeutics 2012
Rocchina Colucci Luca Antonioli Nunzia Bernardini Chiara Ippolito Cristina Segnani Oriana Awwad Marco Tuccori Corrado Blandizzi Carmelo Scarpignato Matteo Fornai

Nonsteroidal anti-inflammatory drugs (NSAIDs) can impair gastric ulcer healing. This study investigates the involvement of NSAID-activated gene-1 (NAG-1) in ulcer repair impairment by cyclooxygenase (COX) inhibitors. Gastric ulcers were induced in rats by acetic acid. Four days later, animals received daily intragastric indomethacin (nonselective COX-1/COX-2 inhibitor; 1 mg/kg), 5-(4-chlorophen...

Journal: :Circulation research 2002
Ken Shinmura Yu-Ting Xuan Xian-Liang Tang Eitaro Kodani Hui Han Yanqing Zhu Roberto Bolli

Cyclooxygenase-2 (COX-2) is known to mediate the cardioprotective effects of the late phase of ischemic preconditioning (PC); however, the signaling pathways involved in COX-2 induction following ischemic PC are unknown. In addition, although inducible nitric oxide synthase (iNOS) has been identified as a co-mediator of late PC together with COX-2, the interaction between iNOS and COX-2 in the ...

2018
Martin Sauerschnig Josef Stolberg-Stolberg Carmen Schmidt Valerie Wienerroither Michael Plecko Karin Schlichting Carsten Perka Christian Dynybil

BACKGROUND Non-steroidal anti-inflammatory drugs are commonly used to reduce pain and inflammation in orthopaedic patients. Selective cyclooxygenase-2 (COX-2) inhibitors have been developed to minimize drug-specific side effects. However, they are suspected to impair both bone and tendon healing. The objective of this study is to evaluate the effect of COX-2 inhibitor administration on tendon-t...

Journal: :Journal of immunology 2003
Michael H Pillinger Pamela B Rosenthal Sonia N Tolani Beth Apsel Victoria Dinsell Jeffrey Greenberg Edwin S L Chan Paul F Gomez Steven B Abramson

We examined the regulation of matrix metalloproteinase (MMP) production by mitogen-activated protein kinases and cyclooxygenases (COXs) in fibroblast-like synoviocytes (FLSCs). IL-1beta and TNF-alpha stimulated FLSC extracellular signal-regulated kinase (ERK) activation as well as MMP-1 and -13 release. Pharmacologic inhibitors of ERK inhibited MMP-1, but not MMP-13 expression. Whereas millimol...

Journal: :Hypertension 2007
William B White

Cyclooxyenase (COX)-2 selective inhibitors were developed to create a new class of nonsteroidal antiinflammatory drugs (NSAIDs) with properties similar to those of nonselective NSAIDS but without their potential COX-1–mediated gastrointestinal toxicities.1,2 Studies of the various COX-2 selective inhibitors have shown that they are in fact associated with a significantly lower risk of upper and...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2006
Adrian Schmassmann Georg Zoidl Brigitta M Peskar Bea Waser Diana Schmassmann-Suhijar Jan-Olaf Gebbers Jean Claude Reubi

Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers. However, the role of COX-1 (with or without impairment of COX-2) and the interaction between COX and NOS isoforms during healing are less clear. Thus we investigated healing and regulation of COX and NOS isoforms during ulcer healing in...

Journal: :Archivum immunologiae et therapiae experimentalis 2000
O Morteau

Prostaglandins (PGs) are arachidonic acid metabolites produced by the action of the enzyme cyclooxygenase (COX). Although PGs are important mediators of inflammation in various diseases, they also are key factors in the physiological regulation of gastrointestinal and renal homeostasis. The finding that two distinct COX isoforms are responsible for PG synthesis has provided basis to the opposit...

Journal: :iranian journal of pharmaceutical sciences 0
muhammad razi ullah khan school of pharmacy, the university of faisalabad, faisalabad, pakistan, department of pharmacy, superior university, lahore, pakistan, faculty of pharmacy, university of sargodha, sargodha, pakistan musaddique hussain school of pharmacy, the university of faisalabad, faisalabad, pakistan shahid masood raza school of pharmacy, the university of faisalabad, faisalabad, pakistan saeed ur rashid nazir faculty of pharmacy, university of sargodha, sargodha, pakistan abrar ahmed department of pharmacy, superior university, lahore, pakistan sidra hasnain department of pharmacy, superior university, lahore, pakistan

non-steroidal anti-inflammatory drugs (nsaids), including selective cyclooxygenase (cox)-2 inhibitors, have come to play an important role in the pharmacologic management of musculoskeletal disorders. clinical trials have established the efficacy of etoricoxib in osteoarthritis, rheumatoid arthritis, acute gouty arthritis, ankylosing spondylitis, low back pain, acute postoperative pain, and pri...

Journal: :Jornal de pediatria 2006
Maria Odete Esteves Hilário Maria Teresa Terreri Cláudio Arnaldo Len

OBJECTIVES To analyze selective COX 2 inhibitor nonsteroidal anti-inflammatory drugs (NSAID) in terms of their mechanism of action, principal indications, posology and most common adverse effects. SOURCES MEDLINE and LILACS databases and Food and Drug Administration (FDA) and National Agency for Sanitary Vigilance (ANVISA - Agência Nacional de Vigilância Sanitária) websites. The most importan...

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