how to cite this article: taghdiri mm, bakhshandeh bali mk, karimzadeh p, ashrafi mr, tonekaboni sh, ghofrani m. comparative efficacy of zonisamide and pregabalin as an adjunctive therapy in children with refractory epilepsy. iran j child neurol. 2015 winter;9(1):49-55. abstract objective approximately one third of epileptic children are resistant to anticonvulsant drugs. this study evaluates t...

Authors of a recent paper [1] concluded that phenobarbitone is more efficacious than phenytoin in control of clinical seizures in term or near-term neonates. However, it has been inferred from apparent misinterpretation of data. The preponderance of seizure type was subtle seizure, which should not be considered as clinical seizure equivalent. Authors themselves mentioned of observations by Miz...

Seizure-suppressor mutations provide unique insight into the genes and mechanisms involved in regulating nervous system excitability. Drosophila bang-sensitive (BS) mutants present a useful tool for identifying seizure suppressors since they are a well-characterized epilepsy model. Here we describe the isolation and characterization of a new Drosophila seizure-suppressor mutant that results fro...

PURPOSE Corpus callosotomy can be an effective surgical treatment for medically intractable generalized seizures, particularly for drop attacks. We studied long-term seizure outcomes after callosotomy, mainly focusing on drop attacks as the seizure type. METHODS This study reviews 78 patients who underwent callosotomy and were followed up for more than 3 years after surgery. Seizure outcome o...

BACKGROUND Neuromodulation-based treatments have become increasingly important in epilepsy treatment. Most patients with epilepsy treated with neuromodulation do not achieve complete seizure freedom, and, therefore, previous studies of vagus nerve stimulation (VNS) therapy have focused instead on reduction of seizure frequency as a measure of treatment response. OBJECTIVE To elucidate rates a...

PURPOSE Lennox-Gastaut syndrome (LGS) is an epileptogenic disorder that arises in childhood and is typically characterized by multiple seizure types, slow spike-and-wave complexes on EEG and cognitive impairment. If medical treatment fails, patients can proceed to one of two palliative surgeries, vagus nerve stimulation (VNS) or corpus callosotomy (CC). Their relative seizure control rates in L...

OBJECTIVE Febrile seizure is the most common type of seizure in children. Their incidence is 2-5%. There are different hypotheses about relationship between neurotransmitters and trace elements (such as zinc) and febrile seizure. Zinc, as a major element of some enzymes, plays an important role in the central nervous system (CNS) and can affect some inhibitory mechanisms of CNS. The aim of the ...

PURPOSE To determine the frequency, causes, risk factors and outcome following early posttraumatic seizure. METHODS A retrospective analysis of age, sex, mechanism of injury, type and onset of unprovoked seizure occurring within one week of injury, admission coma score, and Glasgow outcome score in patients with nonpenetrating head injury. RESULTS Eighty six (10.2%) of 845 head injuredpatie...

UNLABELLED INTRODUCTION Niemann-Pick disease type C is a rare genetic lysosomal storage disease associated with impaired intracellular lipid trafficking and a range of progressive neurological manifestations. The influence of seizure activity on disease course and response to miglustat therapy is not currently clear. CASE PRESENTATION Niemann-Pick disease type C homozygous for NPC1 mutatio...