OBJECTIVE Aim of the study was to assess the efficacy and safety of levetiracetam as add-on treatment in patients with partial-onset epilepsy in clinical practice. METHODS In this observational, multi-centre study patients were treated with levetiracetam for 16 weeks. From a starting dose of 1000 mg/day, dose levels were adjusted at 2-weekly intervals in 1000-mg steps, to a maximum of 3000 mg...

The epilepsies are a heterogeneous group of neurological diseases defined by the occurrence of unprovoked seizures which, in many cases, are correlated with diurnal rhythms. In order to gain insight into the biological mechanisms controlling this phenomenon, we characterized time-of-day effects on electrical seizure threshold in mice. Male C57BL/6J wild-type mice were maintained on a 14/10 h li...

Background Eslicarbazepine acetate (ESL) is a third-generation anti-seizure drug used in patients with focal-onset seizures. This retrospective study aimed to evaluate the efficacy and safety of ESL for treatment epilepsy real-world clinical setting. Methods From March 2022 April 2023, medical records who were prescribed at Gyeongsang National University Changwon Hospital analyzed. Efficacy out...

Focal cortical dysplasia (FCD), a local malformation of cortical development, is the most common cause of pharmacoresistant epilepsy associated with life-long neurocognitive impairments. It remains unclear whether neuronal misplacement is required for seizure activity. Here we show that dyslamination and white matter heterotopia are not necessary for seizure generation in a murine model of type...

Epilepsy is characterized by unprovoked repetitive occurrence of seizures, which are the clinical manifestation of an abnormal cerebral discharge. Seizure semiology is widely variable, in some cases being difficult to identify and diagnose. Especially in nonconvulsive seizures, a high grade of suspicion is necessary and description of episodes by patients and witness may be bizarre and misleadi...

Intravenous microbubble contrast agents are frequently used during ultrasound imaging to improve endocardial border detection, enhance Doppler signals, differentiate thrombi from tumors or define vascular anatomy. Dobutamine stress echocardiography (DSE) with or without addition of atropine is a standard technique for evaluation of coronary artery disease. Noncontrast or contrast-enhanced DSE i...

Congenital rickets is considered a rare disease entity in the newborn period. Hypocalcemic seizure due to congenital rickets has been reported, but this symptom generally appears at the earliest at the end of the first month of life. A congenital rickets case presented unusually with seizure on the first day of life is reported, and the continuing occurrence of the disease with serious conseque...

In the present study 125 cats with recurrent seizures were analysed. The main goal was to investigate the aetiology and compare primary epilepsy (PE) with secondary epilepsy (SE) regarding signalment, history, ictal pattern, clinical and neurological findings. Seizure aetiology was classified as PE in 47 (38%) and SE in 78 (62%) cats. SE was caused mainly by intracranial neoplasia (16), hippoca...

The presence of a generalised seizure is necessary, although not sufficient, for effective ECT. Awareness of this has led to a widespread practice of document ing not only the occurrence but also the duration of seizures; a minimum duration of 25 seconds has been suggested (Royal College of Psychiatrists, 1989).Yet even the most recent surveys of practice have shown that on most occasions when ...

If seizure forecasting systems could reliably identify periods of increased probability of seizure occurrence, patients who suffer from epilepsy would be able to avoid dangerous activities and lead more normal lives. The goal of this project is to differentiate between the preictal and interictal states by analyzing intracranial EEG recordings. Data for each hour are organized into six ten-minu...