OBJECTIVE To evaluate associations between exposure to corticosteroids or sedative-hypnotic medications and incident self-reported depressive symptoms in medical inpatients. METHOD The study utilized a prospective cohort design, focusing on acute depressive symptoms developing soon after medication exposure. The incidence of self-reported depressive symptoms was evaluated using a modified ver...

INTRODUCTION Melissa officinalis is a medical and aromatic plant that is used for its hypnotic, sedative, and spasmolytic effects. This report presents a case study of30-year-old patient who was admitted to an emergency department with restlessness, tremor, distractibility, and sweating following a discontinuation of Melissa officinalis consumption. CASE REPORT In this case, withdrawal sympto...

As well as the traditional sedative/hypnotic group of drugs that relieve anxiety by day and promote sleep at night there are several other groups of drugs that are used to treat insomnia-particularly antidepressant, antipsychotic, and antihistamine drugs. As they differ substantially in their pharmacological and clinical effects on withdrawal I will consider them separately. The seven sleepers ...

Introduction Chlormethiazole is a sedative and hypnotic with marked anti-convulsant properties. It is widely used in the treatment of states characterized by convulsions and agitation, including delirium tremens. Although rarely causing side effects, the drug has been shown to depress the respiratory centre (Lechat, 1966) and toxic interactions with alcohol have been found in animals (Vapaatalo...

Benzodiazepines are agents that enhance the effect of the neurotransmitter c-aminobutyric acid (GABA) on the GABAA receptor, resulting in sedative, hypnotic, sleep-inducing, anxiolytic, euphoric, anticonvulsant and muscle-relaxant properties [1]. These properties make benzodiazepines useful in managing anxiety, insomnia, agitation, seizures, muscle spasms and alcohol withdrawal, and as a pre-me...

Eur J Aneasthesiol Suppl 1997;15:17–20 7. Soar SJ, Smith MB, Soar J, Morris PJ. Does glycine antagonism underlie the excitatory effects of propofol and methohexitone? Br J Anaesth 1992;68:523–6 8. Walder B, Tramèr MR, Seem M. Seizurelike phenomena and propofol. A systematic review. Neurology 2002;58:1327–32 9. Wang B, Bai Q, Jiao W, Wang E, White PF. Effect of sedative and hypnotic doses of pro...

Despite the large number of elderly patients in nursing homes and the intensity of medication use there, few current data are available on patterns of medication use in this setting. We studied all medication use among 850 residents of 12 representative intermediate-care facilities in Massachusetts. Data on all prescriptions and patterns of actual use were recorded for all patients during one m...

benzodiazepines (bzds) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. however, they have some undesired effects including memory problems. in continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...

Purpose: To investigate the sedative, hypnotic and anticonvulsant activities of the ethanol extract of the roots of the Flemingia chappar (ERFC) on the central nervous system (CNS) of mice. Methods: The ethanol extract of the roots of F. chappar in doses of 200, 400 and 600 mg/kg, p.o., was studied in mice for its sedative effect by evaluating its locomotor activity; its hypnotic effect was ass...

BACKGROUND Although most physicians are aware of the potential for abuse and resale of prescribed medications, little has been done to document it. The purpose of this study was to determine which prescription drugs have street value, what that value is and why these drugs are used. METHODS A descriptive cross-sectional survey using a semistructured interview technique was carried out on 2 we...