Introduction: Nardostachys jatamansi DC. is an important ayurvedic plant. The root and rhizome contain active compounds with carminative, sedative, antispasmodic and tranquilizing properties. It is also used as an insect repellent. Essential oil from the drug shows antimicrobial activity against a number of microorganisms. Method: The present study comprises microscopic and macroscopic studies,...

in the present work sedative and hypnotic effects of aqueous extract of aloe vera in rats have been investigated. in order to evaluate the overall hypnotic effects of the aloe vera extract, open field and loss of righting reflex tests were primarily used. the sedative and hypnotic effects of the extract were then confirmed by detection of remarkable raise in the total sleeping time through anal...

Mentha arvensis Linn, a plant used as traditional medicine and in perfumery, has now been explored for its pharmacological activities as an anti-inflammatory and also as sedativehypnotic plant drug. The methanolic extract of the leaves after being processed, was taken for the pharmacological study. Anti-inflammatory activity was carried out on albino rats. Further, the activity was compared to ...

Tianeptine is a selective serotonin reuptake enhancer, possessing strong antidepressant and anxiolytic properties. Its relative lack of sedative, anticholinergic and cardiovascular side effects makes it a highly tolerable substance of abuse. However, physical dependence quickly develops and withdrawal symptoms are common. Abusers in Georgia and Armenia use tianeptine by intravenous injection. D...

In the present study, four non-drug-abusing humans were trained to discriminate between a hypnotic dose of pentobarbital, 100 mg, and placebo. After acquiring the pentobarbital-placebo discrimination, a range of doses of zolpidem, triazolam, pentobarbital and caffeine were tested to determine whether they shared discriminative stimulus effects with the training dose of pentobarbital, Zolpidem, ...