Multiagent systems for a certain application area can be modelled at multiple levels of abstraction. Interlevel relations are a means to relate models from different abstraction levels. Three dimensions of abstraction often occurring are the process abstraction, temporal abstraction, and agent cluster abstraction dimension. In this paper a unifying formalisation is presented that can be used as...

Multiagent systems for a certain application area can be modelled at multiple levels of abstraction. Interlevel relations are a means to relate models from different abstraction levels. Three dimensions of abstraction often occurring are the process abstraction, temporal abstraction, and agent cluster abstraction dimension. In this paper a unifying formalisation is presented that can be used as...

Introduction Present-day transfusion protocols typically specify haemoglobin (Hb) levels as transfusion triggers (i.e. patients below a specified Hb level are almost universally transfused with red blood cells (RBCs), patients above a second threshold are rarely transfused). Between these two Hb levels lies a range (the so called ‘grey area’) in which RBC transfusion practices differ based on e...

Background: Statins, such as simvastatin, are the drugs of choice for the treatment of hypercholesterolemia. On the other hand hypercholesterolmia can occur in hypothyroid patients, who receive levothyroxine. There are few clinical case reports in regards to drug interaction between levothyroxine and lovastatin or simvastatin, indicating decreased levothyroxine effects. This study aimed at dete...

OBJECTIVE Proliferation and migration of vascular smooth muscle cells (SMCs) are central for arterial diseases including atherosclerosis and restenosis. We hypothesized that the underlying mechanisms may be modeled by carotid ligation in mice. In FVB/N inbred mice, ligation leads to abundant neointima formation with proliferating media-derived SMCs, whereas in C57BL/6 mice hardly any neointima ...