Cancer-associated fibroblasts (CAFs) are highly abundant stromal components in the tumour microenvironment. These cells contribute to tumorigenesis and indeed, they have been proposed as a target for anti-cancer therapies. Similarly, targeting Rho-GTPase RAC1 has also suggested potential therapeutic cancer. Here, we show that activity, either pharmacologically or by genetic silencing, increases...

recombinant human interferon alpha 2a (rhifn α -2a) production and cell growth were monitored in a set of genetically modified e. coli strains (msd1519, msd1520, msd 1521, msd 1522, msd 1523) producing rhifn α -2a. the growth was followed at od 600 nm, changes in cell physiology were detected by pyrolysis mass spectrometry (pyms) of cell biomass and recombinant protein production was determined...

This article contains the information about structure, functioning, and regeneration of type 2 pneumocytes. The composition surfactant, processes its synthesis, formation, secretion, distribution redistribution components, as well biological role surfactant in functioning lungs are described detail. development system during embryogenesis is also included. Objectives. To review modern literatur...

Tumor-associated macrophages (TAMs) are the main immune cells in tumor microenvironment (TME) of endometrial cancer (EC). TAMs recruitment and polarization EC is regulated by TME EC, culminating a predominantly M2-like macrophage infiltration. promote lymphatic angiogenesis through cytokine secretion, aid escape synergizing with other cells, contribute to development secretion exosomes so as pr...

miRNAs pose a good prospect in the diagnosis and treatment of type 2 diabetes (T2D). This study is aimed at investigating whether miR-720 targets Rab35 to regulate insulin secretion MIN6 cells its molecular mechanism clinical value as specific biomarker T2D. Fifty-five samples new T2D patients normal control were collected. Levels miR-720, fasting blood glucose, insulin, other indicators glucos...

The granins, known to be general constituents of neuroendocrine secretory granules, are regulators of the proteolytic processing of peptide precursors and promote their aggregation-mediated sorting into secretory granules.

Numerous studies have examined the effects of COVID-19 pandemic on women’s mental health and menstrual cycles. However, most these only included outpatients with COVID-19, whereas information hospitalised women is minimal. ACE 2 essential for SAR-CoV2 virus to enter human cells ovary. Since it stimulates steroid secretion, aids in follicle development oocyte growth, influences ovulation, mainta...

Ingestion of alkaline substances can cause mucosal damage and upper airway obstruction, which is a serious potentially fatal complication. An 80-year-old patient ingested small amount liquid presented to our hospital with burning sensations in the throat. Within two hours arrival, edema epiglottis rapidly worsened excessive secretion, resulting obstruction. We attempted intubate using fiberopti...

Herbal utilization, as an antidiabetes agent, is interesting topic to find acceptable herbal drugs decrease blood glucose levels. The aim of this review evaluate the potency selected medicines reduce levels and identify chemical compounds responsible for reducing glucose. mechanisms action different used might be also different. reduction by Aloe vera, Andrographis paniculata, Trigonella foenum...

Introduction/Aim: Spondylodysplastic Ehlers-Danlos Syndrome (sdEDS) is a rare genetic disorder of collagen synthesis, caused by mutation in the B4GALT7, B3GALT6, or SLC39A13 gene. Features this very are short stature, hypotonia, hyperflexible joints, soft, thin, and overly stretchable skin, sparse hair eyebrows, elderly face, wide forehead prolonged wound healing. Molecular analysis needed for ...