نتایج جستجو برای: secreted expression

تعداد نتایج: 898666  

Journal: :Molecular therapy : the journal of the American Society of Gene Therapy 2014
Jack M Milwid Jessica S Elman Matthew Li Keyue Shen Arjun Manrai Aaron Gabow Joshua Yarmush Yunxin Jiao Anne Fletcher Jungwoo Lee Michael J Cima Martin L Yarmush Biju Parekkadan

The secreted proteins from a cell constitute a natural biologic library that can offer significant insight into human health and disease. Discovering new secreted proteins from cells is bounded by the limitations of traditional separation and detection tools to physically fractionate and analyze samples. Here, we present a new method to systematically identify bioactive cell-secreted proteins t...

Journal: :Cell host & microbe 2016
Christina M Homer Diana K Summers Alexi I Goranov Starlynn C Clarke Darin L Wiesner Jolene K Diedrich James J Moresco Dena Toffaletti Rajendra Upadhya Ippolito Caradonna Sarah Petnic Veronica Pessino Christina A Cuomo Jennifer K Lodge John Perfect John R Yates Kirsten Nielsen Charles S Craik Hiten D Madhani

Quorum sensing (QS) is a bacterial communication mechanism in which secreted signaling molecules impact population function and gene expression. QS-like phenomena have been reported in eukaryotes with largely unknown contributing molecules, functions, and mechanisms. We identify Qsp1, a secreted peptide, as a central signaling molecule that regulates virulence in the fungal pathogen Cryptococcu...

Journal: :Medical mycology 2009
Wenchuan Leng Tao Liu Jin Wang Ruoyu Li Qi Jin

Trichophyton rubrum is the most common agent of dermatophytosis, a disease that affects millions of individuals worldwide. Its molecular pathogenicity mechanisms are still not completely elucidated. It has been widely recognized that proteases secreted by T. rubrum are the key virulence factors during host infection. However, our knowledge about the expression of its secreted proteases in host ...

Journal: : 2021

Effectors are specific proteins secreted by nematodes into plant cells that facilitate their parasitism to host plants. Inactivation of these effectors could reduce the parasitic ability on plants and damage caused nematodes. Gene Minc14137encodes an effector unknown function is cloned from Meloidogyne incognita. Artificial microRNAs capable inactivating gene Minc14137 were synthesised inserted...

2013
Chunxia Peng Xiaobei Yin Mengda Li Ting He Genlin Li

Neurotrophin-3 (NT-3) can promote the repair of central nervous system and retinal damage. In previous reports, NT-3 has been expressed by viral vectors. However, plasmid vectors have a safer profile compared with viral vectors in clinical studies. This study recombined amplified human retinal NT-3 with a eukaryotic expression plasmid containing green fluorescent protein (GFP) to construct an N...

Journal: :Molecular microbiology 2007
Thierry Doan David Z Rudner

During sporulation in Bacillus subtilis, the mother cell membranes migrate around the forespore in a phagocytic-like process called engulfment. Developmental gene expression requires the successful completion of this key morphological event. Here we show that perturbations to engulfment block the accumulation of proteins secreted into the space between the mother cell and forespore membranes. O...

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