Poly(glycerol sebacate) (PGS) is a biodegradable polymer increasingly used in a variety of biomedical applications. This polyester is prepared by polycondensation of glycerol and sebacic acid. PGS exhibits biocompatibility and biodegradability, both highly relevant properties in biomedical applications. PGS also involves cost effective production with the possibility of up scaling to industrial...

The hydrolysis of the esters of the dicarboxylic fatty acids, malonic and succinic, by lipase has not been the subject of careful study. Doyen and Morel (1) observed that serum lipase caused hydrolysis of diethyl succinatc? but the results are difficult of interpretation from a quantitative standpoint. Kastle (2) stated that diethyl succinate was readily hydrolyzed by liver lipase, but cited no...

Dicarboxylic acids are prominent features of several diseases, including Reye's syndrome. Long-chain dicarboxylic acids have profound effects on the function and structure of isolated mitochondria, suggesting that they could contribute to the mitochondrial dysfunction in Reye's syndrome. Binding of fatty acids to albumin and the intracellular fatty acid-binding proteins is important in regulati...

Biodegradable nanoparticles have emerged as a versatile platform for the design and implementation of new intranasal vaccines against respiratory infectious diseases. Specifically, polyanhydride nanoparticles composed of the aliphatic sebacic acid (SA), the aromatic 1,6-bis(p-carboxyphenoxy)hexane (CPH), or the amphiphilic 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) display unique bulk an...

Soft and stretchable electronic devices are expected to offer technological advances in the field of robotics, human–machine interfacing, healthcare. Employing biodegradable elastomers, hydrogels, nontoxic conductors would add significant value minimize ecological impact such disposable transient applications. Here, photo-crosslinkable elastomer poly(glycerol sebacic) acrylate (PGSA) is charact...