© 2018 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow A 56‐year‐old male patient presented with a solitary asymptomatic growth over the chin since 3 years [Figure 1]. There was history of trauma to the chin while shaving followed by development of a small raised lesion over the same site. There was history of gradual increase in size of the lesion over a period of 2 yea...

PLA2 (phospholipase A2) group III is an atypical sPLA2 (secretory PLA2) that is homologous with bee venom PLA2 rather than with other mammalian sPLA2s. In the present paper, we show that endogenous group III sPLA2 (PLA2G3) is expressed in mouse skin and that Tg (transgenic) mice overexpressing human PLA2G3 spontaneously develop skin inflammation. Pla2g3-Tg mice over 9 months of age frequently d...

The complex anatomy of the epidermis contains multiple adult stem cell populations, but the extent to which they functionally overlap during homeostasis, wound healing, and tumor initiation remains poorly defined. Here, we demonstrate that Lrig1(+ve) cells are highly proliferative epidermal stem cells. Long-term clonal analysis reveals that Lrig1(+ve) cells maintain the upper pilosebaceous unit...

Tumors produced by 2-acetylaminofluorene occur with differing frequencies in various organs. The squamous-cell carcinomas of the auditory canal region, reported in the original experiment of Wilson, De Eds, and Cox (23), appear to be of particular interest. There has been considerable discussion in the literature as to their site of origin and mode of development. In our experiment this type of...

The face is known to be the most frequent site for sebaceous hyperplasia (SH); in fact, this particular pathology has rarely been reported in other sites, as for instance the areole. The first case of the areolar SH (ASH) was described in 1985 in a 37-year-old woman, presenting as bilateral diffuse thickening of the areolas. In the course of the years, few other cases of bilateral and unilatera...