نتایج جستجو برای: sdf1
تعداد نتایج: 329 فیلتر نتایج به سال:
BACKGROUND Animal and clinical studies have revealed that focal peripheral nerve axon demyelination is accompanied by nociceptive pain behavior. C-C and C-X-C chemokines and their receptors have been strongly implicated in demyelinating polyneuropathies and persistent pain syndromes. Herein, we studied the degree to which chronic nociceptive pain behavior is correlated with the neuronal express...
Carcinoma-associated fibroblasts (CAF) play a critical role inmalignant progression. Loss of TGF-b receptor II (TGFbR2) in the prostate stroma is correlated with prostatic tumorigenesis. To determine the mechanisms by which stromal heterogeneity because of loss of TGFbR2 might contribute to cancer progression, we attenuated transforming growth factor beta (TGF-b) signaling in a subpopulation of...
In this study, we have characterized the signaling pathways mediated by CXCR4 in breast cancer cells and its role in breast cancer cell invasion and migration. Stromal cell-derived factor 1A (SDF-1A; CXCL12) stimulation of breast cancer cells resulted in phosphoinositide 3-kinase (PI-3K) activation, AKT phosphorylation, and activation of the FKHRL1 transcription factor. In addition, SDF-1A indu...
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