Background: Intravenous immunoglobulin (IVIG) was originally licensed as antibody replacement therapy in patients with primary immunodeficiencies. Subsequent experimental use of IVIG during the last several decades, however, has shown that it is effective in numerous medical conditions. Currently there are six United States, Food and Drug Administration approved clinical indications for IVIG in...

The pathogenesis of systemic sclerosis (SSc) involves complex interactions between activated fibroblasts eventually leading to fibrosis, and impaired immune tolerance characterized by a variety of circulating SSc-specific autoantibodies. The expression of autoantigens in fibroblasts, a key target tissue in SSc, may play an important role in this process. To obtain a global view of this process,...

Monoclonal gammopathy represents a condition characterized by clonal proliferation and accumulation of immunoglobulin producing B-cells. A variety of skin disorders are associated with an increased level of monoclonal immunoglobulin proteins. These skin disorders can be divided into two groups. The first group represents a direct consequence of plasma cell proliferation. The colonization of the...

BACKGROUND Onchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness. METHODS A clinical classification system of the cutaneous changes in onchocerciasis was used for the first time in this study within the context of an early ivermectin drug trial in the savanna region of Kaduna State, northern Nigeria. Skin examinations were...

Discrete papular lichen myxedematosus (DPLM), asubset of localized lichen myxedematosus, is a rarecutaneous mucinosis of unknown etiology. We reporta case of a 57-year-old woman with palmoplantarpsoriasis who developed DPLM 8 weeks after addingustekinumab to a long-term course of methotrexate.The patient had previously failed 2 prior tumor necrosisfactor (TNF) inhibitors, adalimumab and etanerc...

or hypothyroidism. (b) Medical therapy: frequent and prolonged, with the need for supervision, the risk of toxic reactions, and the chance of eventual failure. Surgical mortality may be small but is present in most of the recQrded series (Hayles, Kennedy, Beahrs, and Woolner/ 1959; Kunstadter and Stein, 1955; McClintock, Frawley, and Holden, 1956; Van Wyk, Grumbach, Shepard, and Wilkins, 1956) ...

Oral focal mucinosis pdf Oral focal mucinosis: report of two cases. Mucinose oral focal: relato de dois casos.Oral focal mucinosis OFM is a rare soft tissue lesion of unknown etiology. oral focal mucinosis of the tongue Clinically, it is most commonly found on the gingiva and presents as a painless.Oral focal mucinosis OFM, an oral counterpart of cutaneous focal mucinosis, is a rare. oral focal...

Acral persistent papular mucinosis (APPM) is a rare subtype of localized lichen myxedematosus. It consists of small papules localized exclusively on the back of the hands, wrists and extensor aspects of distal forearms with no other clinical or laboratory manifestations. The lesions tend to persist and may increase slowly in number. Histologically, hematoxylin-eosin and Alcian blue staining dem...

Indian Dermatology Online Journal | January-February 2017 | Vol 8 | Issue 1 63 Other differential diagnosis to be considered for such distinctive skin lesions are connective tissue nevi, localized amyloidosis, and papular mucinosis. Connective tissue nevus can occur at different sites as compared to the patterned distribution of skin lesions in Hunter’s syndrome. Lack of inflammation and prurit...