Sickle cell disease (SCD) results in neuropsychological complications that place adolescents at higher risk for limited educational achievement. A first step to developing effective educational interventions is to understand the impact of SCD on school performance. The current study assessed perceptions of school performance, SCD interference and acceptability of educational support strategies ...

Background Neurodegeneration of cholinergic pathways may be present in individuals with subjective cognitive decline (SCD). However, variability between SCD the integrity needs to elucidated. Our objective was determine characteristics neurodegeneration different subtypes (i.e. amnestic vs. non-amnestic). Method Individuals (n = 47), non-amnestic 38), and healthy controls without complaints (HC...

Introduction: The avascular osteonecrosis of the femoral head (AOFH) is a common complication sickle cell disease (SCD). It exposes to lameness and sometimes very debilitating handicap. source desocialization, particularly in developing countries where prosthetic surgery remains inaccessible majority. This survey aimed identify risk occurence AOFH.
 Materials Methods: was case-control stud...

Toxoplasmosis is a serious disease caused by Toxoplasma gondii, one of the most widespread parasites in the world. Lipid metabolism is important in the intracellular stage of T. gondii. Stearoyl-CoA desaturase (SCD), a key enzyme for the synthesis of unsaturated fatty acid is predicted to exist in T. gondii. Sterculic acid has been shown to specifically inhibit SCD activity. Here, we examined w...

INTRODUCTION Growth retardation and under-nutrition are common in children with sickle cell disease (SCD). The aim of this study was to compare the head circumference (HC) of SCD children and non-SCD children and to determine the effect of malnutrition on head circumference of children with SCD. METHODS This was a prospective case-control study conducted at the Lagos State University Teaching...

Many African Americans with sickle cell disease (SCD) also experience significant economic hardship. Yet, few studies of the psychosocial effects of SCD employ designs robust enough to control socioeconomic factors. This study compares the functioning of families with SCD to that of healthy controls matched for race and socioeconomic status. In general, functioning within SCD and control famili...

OBJECTIVE Epilepsy is associated with increased risk for sudden cardiac death (SCD). We aimed to establish, in a community based study, whether this association is mediated by epilepsy per se, use of antiepileptic medications (AEMs), or both. METHODS We studied SCD cases and age/sex matched controls in a case-control study in a large scale general practitioners' research database (n=478 661 p...

BACKGROUND AND OBJECTIVE Females with sickle cell disease (SCD) often show late onset of menarche. In transgenic sickle cell mouse, deficiency of gene encoding endothelial nitric oxide synthase (eNOS) has been reported to be associated with late onset of menarche. Thus to explore the possible association of eNOS gene polymorphism with age of onset of menarche in SCD females, 3 important eNOS ge...

Objective: To determine whether the C-reactive protein (CRP) can help identify which febrile patients with sickle cell disease (SCD) require antibiotic therapy. Patients and Methods: We performed a chart review of patients with SCD (including S-S, S-C, and S-Thal) admitted to the hospital with fever [temperature >38.3C <2 years of age; >38.9C ≥2 years of age] over a thirty-month period (July 20...

BACKGROUND T-wave alternans (TWA) is a well-documented noninvasive electrocardiographic (ECG) method useful for identifying patients at risk for sudden cardiac death (SCD). OBJECTIVE The purpose of this study was to evaluate whether the long-term average TWA activity on Holter monitoring provides prognostic information in patients with chronic heart failure. METHODS Twenty-four-hour Holter ...