The aim of this paper was to evaluate the effects associated with intramammary infection (IMI) by a bacterium or a group of bacteria (Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, coliforms, Staphylococci other than S. aureus, and Corynebacterium bovis) on the somatic cell count (SCC) in quarter milk of dairy cows. Papers selected for analysi...

The precise mechanisms governing invasion at the leading edge of squamous cell carcinoma (SCC) and its subsequent metastasis are not fully understood. We aimed to define the cancer-related molecular changes that distinguish noninvasive tumor from invasive SCC. To this end, we combined laser capture microdissection with complementary DNA (cDNA) microarray analysis. We defined invasion-associated...

BACKGROUND/AIM Cigarette smoke (CS) is the main inducer of oral cancer, increasing the prevalence by 4-7 times. We examined induction of apoptosis by CS exposure of SCC-25 and SCC-15 oral cancer cells. MATERIALS AND METHODS After controlled exposure to CS of various durations and at different time points we measured DNA fragmentation to assay apoptotic levels. RESULTS SCC-15 cells showed a ...

Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. Here, we identify the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC in mice, and demonstrate that targeting of Grhl3 by a miR-21-dependent proto-oncogenic network underpins SCC in humans. Deletion of Grhl3 in adult epidermis evokes loss of expression of PTEN, a ...

The incidence and prevalence of premalignant and malignant skin lesions including squamous cell carcinoma (SCC) of the skin are increasing worldwide. The aim of the study was to determine TP53, Bcl-2 and growth hormone receptor (GHR) expression in SCC and to investigate relative importance of these proto-oncogenes in its biological behavior. Expression of TP53, Bcl-2 and GHR was determined by i...

Longstanding renal calculus is a risk factor of squamous cell carcinoma (SCC) of the renal pelvis. It is highly aggressive and usually diagnosed at advanced stages with a poor prognosis. We present two cases of kidney stone complications with renal pelvic SCC. These two patients had a radical nephrectomy and the dissected tissues were renal pelvic SCC. Our cases further emphasize that renal pel...

AE monitoring from various types of stress corrosion cracking (SCC) has been conducted for the past 15 years in our laboratory. This paper discusses AE results of active-path dissolution-type SCC of austenitic stainless steel in chloride solution and fused salt, fluoride and polythionic acid solutions, brass in ammonia (Mattosson's solution), and carbon steels in nitrite solution. Transgranular...

Human microRNA 184 (miR-184) is overexpressed in squamous cell carcinoma (SCC) of the tongue. In vitro inhibition of miR-184 levels could induce apoptosis and hinder proliferation of tongue SCC cells. Patients with tongue SCC have high plasma miR-184 levels. Plasma miR-184 is likely associated with the tumor load. Surgical removal of the primary tumor reduced plasma miR-184 levels significantly...

Squamous cell carcinoma (SCC) of the oral cavity and pharynx represents the sixth most common form of malignancy worldwide. A significant proportion of these cases are related to human papillomavirus (HPV) infection. In general, HPV-associated SCC is more commonly nonkeratinizing and poorly differentiated, whereas non-HPV-associated SCC is typically keratinizing and moderately differentiated. N...

BACKGROUND The PTCH expression level in esophageal squamous cell carcinoma (SCC) was examined. MATERIALS AND METHODS To test whether PTCH can serve as a candidate marker for esophageal SCC, a quantitative reverse transcription (RT) -PCR for the PTCH gene was performed and the possible relationship between PTCH gene expression levels and clinicopathological findings in esophageal SCC was evalu...