The application of digital imaging technologies including confocal scanning laser ophthalmoscopy (CSLO), optical coherence tomography (OCT), and scanning laser polarimetry (SLP) has significantly improved the detection of optic nerve head (ONH) deformation and progressive retinal nerve fiber layer (RNFL) thinning for assessment of glaucoma progression. Algorithms for change analysis such as top...

OBJECTIVES To summarise the methods of the European Prospective Investigation of Cancer (EPIC)-Norfolk Eye Study, and to present data on the prevalence of visual impairment and associations with visual impairment in the participants. DESIGN A population-based cross-sectional study nested within an on-going prospective cohort study (EPIC). SETTING East England population (the city of Norwich...

The ONH can be examined using a direct ophthalmoscope, an indirect ophthalmoscope, or a posterior pole lens with a slit lamp. Many types of health professional can assess the ONH accurately after having appropriate training. Dilating the pupil makes this easier and will improve the accuracy of the examination, regardless of which instrument is used. Where the equipment is available, more sophis...

INTRODUCTION For many years, ophthalmologists have looked at the optic nerve head to evaluate the status of glaucoma. Clinical examination of the optic nerve head and retinal nerve fibre layer (RNFL) is however, subjective and sometimes variable. Recent developments in computer-based imaging technologies have provided a means of obtaining quantitative measurements of the optic nerve head topogr...

PURPOSE To provide an update on the role of optic nerve head and peripapillary retinal nerve fiber layer imaging in monitoring glaucoma progression. METHODS Review of literature. RESULTS Imaging technologies, such as optical coherence tomography, scanning laser polarimetry, and confocal scanning laser ophthalmoscopy, objectively and quantitatively measure the structural change associated wi...

Purpose. To investigate transient focal microcystic retinoschisis in glaucomatous eyes in images obtained with several imaging techniques used in daily glaucoma care. Methods. Images of 117 glaucoma patients and 91 healthy subjects participating in a large prospective follow-up study into glaucoma imaging were reviewed. Participants were measured with spectral domain optical coherence tomograph...

PURPOSE The genetic etiology of primary open-angle glaucoma (POAG) is still largely unknown, because of its complexity and disparities in its classification. This study was undertaken to determine the genetic contribution to various early, continuous markers of POAG by assessing the heritability of intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness, and neuroretinal rim and ...

Advantages of the e−e− option at linear colliders for the study of supersymmetry are highlighted. The fermion number violating process e−e− → ẽ−ẽ− provides unique opportunities for studies of slepton masses and flavor mixings. In particular, slepton mass measurements at the 100 MeV level through threshold scans of scalar pair production may be possible. Such measurements are over an order of ma...

PURPOSE To evaluate changes in retinal nerve fiber layer thickness as measured by scanning laser polarimetry (SLP) after the use of medication to reduce intraocular pressure (IOP) in glaucomatous or ocular hypertensive patients. METHODS The authors prospectively enrolled 37 eyes of 37 patients in whom IOP was reduced by more than 25% after the use of medication. The images were obtained befor...

Micro-interferometric backscatter detection (MIBD) is performed with a simple, folded optical train based on the interaction of a diode laser beam and a fused silica capillary tube allowing for refractive index (RI) determinations and detection of optically active molecules in small volumes. Side illumination of the capillary by a laser produces a 360◦ fan of scattered light that contains two s...