The most abundant volatile occurring in mushrooms and responsible for the mushroom odour is 1-octen-3-ol. To meet the demand for a flavour compound yielding a mushroom odour a study was carried out on the possibility of obtaining 1-octen-3-ol synthetically. On the basis of literature data and experiments performed, the synthesis of this compound was carried out by two methods, i.e. by Grignard ...

The essential oil of Clausena anisum-olens (Blanco) Merr. showed strong contact toxicity and repellency against Lasioderma serricorne and Liposcelis bostrychophila adults. The components of the essential oil obtained by hydrodistillation were determined by gas chromatography-mass spectrometry. It was found that the main components were myristicin (36.87%), terpinolene (13.26%), p-cymene-8-ol (1...

BACKGROUND Patients undergoing conventional hemodialysis (C-HD) present a greater immuno-inflammatory state probably related to uremia, sympathetic nervous system (SNS) activation and /or membrane bioincompatibility, which could improve with a technique-switching to online hemodiafiltration (OL-HD). The antigen-independent pathway activation of this modified immunologic state turns dendritic ce...

BACKGROUND Renal renin-angiotensin system (RAS) activation is one of the important pathogenic mechanisms in the development of diabetic nephropathy in type 2 diabetes. The aim of this study was to investigate the effects of a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, dapagliflozin, on renal RAS in an animal model with type 2 diabetes. METHODS Dapagliflozin (1.0 mg/kg, OL-DA) or vogl...

This study reports, for the first time, chemical composition and biological activity of essential oil from Brazilian Cymbopogon densiflorus flowers. Thirty compounds were identified by gas chromatography coupled with mass spectrometry (GC/MS), corresponding to 95 % total an chromatogram obtained chromatography-flame ionization detection (GC-FID ). The was mainly composed cis-p-mentha-1(7),8-die...

This experiment was conducted to investigate the effects of olive leaf (OL) on immune response and some blood metabolites of broiler chickens. A total of 400 one-day-old broiler chicks (male and female) were randomly assigned to 5 experimental treatments with 4 replicates of 20 birds each. Birds of different treatments were given diets containing 0, 0.25, 0.5, 0.75 and 1% OL powder from 14 to 4...

The lipase B from Candida antarctica (Novozym 435®, CALB) efficiently catalyzed the kinetic resolution of some aliphatic secondary alcohols: (±)-4-methylpentan-2-ol, (±)-5-methylhexan-2-ol, (±)-octan-2-ol, (±)-heptan-3-ol and (±)-oct-1-en-3-ol. The lipase showed excellent enantioselectivities in the transesterifications of racemic aliphatic secondary alcohols producing the enantiopure alcohols ...

Cell membrane thyroid hormone (TH) transport can be facilitated by the monocarboxylate transporter 8 (MCT8), encoded by the solute carrier family 16 member 2 (SLC16A2) gene. Human mutations of the gene, SLC16A2, result in the X-linked-inherited psychomotor retardation and hypomyelination disorder, Allan-Herndon-Dudley syndrome (AHDS). We posited that abrogating MCT8-dependent TH transport limit...

BACKGROUND Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants. It has been suggested that white matter injury in this condition is due to altered oligodendrocyte (OL) development or death, resulting in OL loss and hypomyelination. At present drugs are not availabl...

OLs (oligodendrocytes) are the myelinating cells of the CNS (central nervous system), wrapping axons in conductive sheathes to ensure effective transmission of neural signals. The regulation of OL development, from precursor to mature myelinating cell, is controlled by a variety of inhibitory and inductive signalling factors. The dorsal spinal cord contains signals that inhibit OL development, ...