Gaucher disease (GD) is characterized by accumulation of glucosylceramide (GC) in the cells of monocyte/macrophage system. The degradation of GC is controlled by glucosylceramidase (GCase) and saposin (Sap) C, a member of a family of four small glycoproteins (Saps A, B, C and D), all derived by proteolytic processing of a common precursor, prosaposin (PSAP). Saps contain six cysteine residues, ...

Bu çalışmada, daha önce teorik ve deneysel çalışmaları yapılan alt başlığı eğrisel, ön germeli kirişin, kiriş orta kesit yüksekliğine göre burkulma davranışı incelenip ideal yüksekliğinin belirlenmesi amaçlanmıştır. Bunun için Sap 2000 programında 250 civarı sonlu elemanlar modeli hazırlanarak analizleri yapılmıştır. İlaveten FEMAP (Nastran) Sonlu analizi programı ile de modele uygun solid oluş...

Highly specific, high-resolution scintigraphic images of amyloid-laden organs in mice with experimentally induced amyloid A protein (AA) amyloidosis were obtained after intravenous injection of 123I-labeled serum amyloid P component (SAP). Interestingly, a much higher proportion (up to 40%) of the injected dose of heterologous human SAP localized to amyloid and was retained there than was the c...

Serum amyloid P (SAP) is a common component of human amyloid deposits and has been identified in atherosclerotic lesions. We investigated the extent of the colocalization of SAP with apolipoprotein A-I (apoA-I), apoB, apoC-II, and apoE in human coronary arteries and explored potential roles for SAP in these regions, specifically the effect of SAP on the rate of formation and macrophage recognit...

Many different techniques have been used for xylem sap collection, but few direct comparisons of techniques have been conducted and few comparisons have been based on comprehensive analyses of xylem sap. Moreover, the suitability of extraction techniques for use on plants grown under water-stress conditions has not been addressed. Xylem sap was extracted from both well-watered and water-stresse...

BACKGROUND/AIMS Upregulated CD64 expression on neutrophils is the most useful marker for acute bacterial infections and systemic inflammation. However, it is unknown whether CD64 is involved in the pathogenesis of acute pancreatitis (AP). This study was designed to determine whether CD64 is implicated in severe acute pancreatitis (SAP), and thus, is a suitable marker for SAP. METHODS SAP was ...

A full decomposition of the predictive entropy (PE) of the spontaneous variations of the heart period (HP) given systolic arterial pressure (SAP) and respiration (R) is proposed. The PE of HP is decomposed into the joint transfer entropy (JTE) from SAP and R to HP and self-entropy (SE) of HP. The SE is the sum of three terms quantifying the synergistic/redundant contributions of HP and SAP, whe...

In this present study aims to evaluate the performance of base isolation device under different intensity blast induced ground excitations for an elevated water tank staging. mainly focused improve isolator and minimize damage structure. To know two models are considered one is fixed model another supported with both non-linear time history analysis carried out help SAP 2000 software subjected ...

SAP applications can often comprise the core of IT operations in large enterprises. Companies that outsource their SAP landscape and basic operation to a private cloud can manage their resources flexibly in a way that meets demand and saves costs. Dynamic Services for SAP Solutions* and Application Operations for SAP Solutions* form a private cloud solution from TSystems which comprises both th...

Indonesia merupakan wilayah yang berada pertemuan tiga lempeng aktif yaitu, Indo-Australia, Eurasia, dan Pasifik juga pada jalur cincin api atau ring of fire, menyebabkan sering terjadinya gempa bumi di Indonesia. Dalam perencanaan bangunan seperti Sistem Rangka Pemikul Khusus (SRPMK) bagian dari Momen (SRPM) memang digunakan dengan resiko tinggi terhadap bumi. Proses perancangan suatu gedung m...