PURPOSE OF REVIEW Adjuvant and salvage radiotherapy after radical prostatectomy have an established role in the management of high-risk patients. We discuss contemporary data on optimal timing and doses of radiotherapy, role of hormonal therapy and pelvis irradiation, and toxicity. RECENT FINDINGS Positive surgical margins are not predictive of reduced overall survival, even in patients treat...

Despite local therapy with curative intent, approximately 30% of men suffer from biochemical relapse. Though some of these PSA relapses are not life threatening, many men eventually progress to metastatic disease and die of prostate cancer. Local therapy is an option for some men, but many have progression of disease following local salvage attempts. One significant issue in this setting is the...

Objectives: To analyse and present the data of our cryosurgery experience for the treatment of prostate cancer. Methods: Between August 2003 and November 2006, a total of 91 patients were treated with cryosurgery for prostate cancer as either primary treatment (n = 49) or salvage treatment (n = 42). The mean follow-up was 19.16 mo (range: 6 wk to 6 mo). Data were collected prospectively. Result...

BACKGROUND The treatment modalities for recurrent locally advanced head and neck cancer failure after radiotherapy are limited with poor prognosis. Salvage supra-radical operation seems to be an option. It has not been established which patients will benefit from salvage total pharyngolaryngoesophagectomy. METHODS We retrospectively reviewed 66 patients with previously irradiated recurrent T4...

INTRODUCTION Currently there is no universally accepted approach for the management of radiation-recurrent prostate cancer. The aim of this study was to detail our experience performing salvage radical prostatectomy for patients who failed primary treatment of prostate cancer with radiation therapy. MATERIAL AND METHODS We retrospectively queried our institutional database of radical prostate...

BACKGROUND Osteosarcoma is a high malignant neoplasm, and conflicting findings have been reported on the survival and function recovery of osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared limb salvage surgery (LSS) with amputation in clinical outcomes of osteosarcoma patients by a meta-analysis. METHODS The survival rate of osteosarcoma patients...

Organ preservation treatment for advanced head and neck squamous cell carcinoma is associated with poor outcomes due to locoregional recurrences. Salvage surgery is the main therapeutic option for some of these patients. The aim of this study was to analyse the results of salvage surgery for advanced pharyngolaryngeal squamous cell carcinoma previously treated with radiochemotherapy. We perform...

OBJECTIVES/HYPOTHESIS Local residual or recurrent pharyngeal cancer after definitive radiotherapy (RT) or chemoradiotherapy (CRT) is correlated to poor prognosis. We analyzed the efficacy of salvage surgery for patients with local residual or recurrent pharyngeal cancer after RT or CRT. STUDY DESIGN Retrospective clinical study with chart review. METHODS Between 2001 and 2011, we treated 20...

Radiotherapy (RT) or chemoradiotherapy (CRT) is a potentially curative, non-surgical treatment option for esophageal cancer, although the rate of local failure within the esophagus remains relatively high. Salvage esophagectomy is not regarded as a common treatment for esophageal cancer, since it is a high-risk surgery with a relatively high surgical mortality rate. Salvage endoscopic resection...

The flux activities of de novo and salvage purine synthesis were compared in rat hepatoma 3924A cells in various growth phases. The initial rate assays of [I4C]adenine, ("C]hypoxanthine, and |"C]guanine incorporation yielded Michaelis-Menten kinetics with A'msof 5, 7, and 7 #tM,respectively. After replating plateau phase cells in lag and log phases the activity of purine de novo pathway increas...