Myoepithelial cells (MECs) mainly surround acini and intercalated ducts in the human salivary glands. The contraction of MECs provides the expulsive force to promote salivation. We previously found functional transient receptor potential vanilloid subtype 1 (TRPV1) was expressed in rabbit and human submandibular glands and increased saliva secretion. However, it was unknown whether TRPV1 was ex...

This study was carried out to evaluate the effect of administration of aspartame in two doses (40mg/kg and 80mg/kg body weight) on the submandibular salivary glands of male albino rats. Ninety adult male rats weighing (200-250g) were used in this study. Animals in each group were caged in separate cages in the animal house at the Faculty of Dentistry, Minia University. Pure aspartame (APM) powd...

Sjögren's syndrome (SS), an autoimmune exocrinopathy, is associated with dysfunction of the secretory salivary gland epithelium, leading to xerostomia. The etiology of SS disease progression is poorly understood as it is typically not diagnosed until late stage. Since mouse models allow the study of disease progression, we investigated the NOD/ShiLtJ mouse to explore temporal changes to the sal...

Background: Sclerosing polycystic adenosis (SPA) is a rare, recently described, tumorous condition of the major or minor salivary glands that on gross and microscopic evaluation mimics an invasive carcinoma. The histology quite similar to seen in fibrocystic disease, sclerosing tumors breast. It also resembles more diffuse bilaterally occurring dysgenetic disease (PDD) parotid gland. To best ou...

Tramadol is a centrally acting analgesic with weak opioid agonist properties, which also has monoaminergic activity, exerted via inhibition of neuronal uptake serotonin and norepinephrine. generally well tolerated the most common adverse events are nausea, dizziness, drowsiness, sweating, vomiting dry mouth. The effect intraperitoneal injection tramadol pilocarpine were studied in rats on flow ...

Many authors have assumed that the reason supragingival calculus tends to form preferentially on the lingual surface of the 6 lower anterior teeth is because saliva from the adjacent submandibular ducts is a source of calcium and phosphate ions and because loss of CO2 as the saliva enters the mouth increases the local pH. However, the fluid phase of plaque in all locations is supersaturated wit...

Adenoid cystic carcinoma (ACC) is an aggressive malignant neoplasm of the salivary glands in which c-Kit is overexpressed and activated, although the mechanism for this is as yet unclear. We analyzed 27 sporadic ACC tumor specimens to examine the biologic and clinical significance of c-Kit activation. Mutational analysis revealed expression of wild-type c-Kit in all, eliminating gene mutation a...

Mucous retention cysts are the most common disorder of the minor salivary glands. An occlusion of the ducts of the minor salivary glands can lead to retention of mucus, and this change can in turn cause cyst formation. They are most commonly encountered in the lower labial mucosa but can affect any part of the oral mucosa and the involvement of the soft palate is rare. Salivary mucoceles may be...

Salivary gland cells are joined by junctional complexes consisting of a tight junction (TJ), zonula adherens and one or more desmosomes. TJs regulate paracellular permeability, maintain separate apical and basolateral membrane domains, and serve as signaling centers. We examined TJs of mouse submandibular glands (SMG) in thin sections and freeze-fracture replicas. TJs between acinar cells and b...