treated surgically or nonsurgically. Nonsurgical treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), including salicylates, is typically indicated for long bone lesions in inaccessible or central locations where en bloc excision might result in major morbidity or fracture. Chronic, intermittent administration of NSAIDs is continued until the osteoid osteoma spontaneously involutes, us...

The inhibition of the spreading effect of hyaluronidase by the previous administration of sodium salicylate was reported by Guerra and Robles Gil (1). Subsequent investigations indicated that this phenomenon could not be explained on the basis of the direct inhibition of hyaluronidase by salicylates, since such inhibition could only be demonstrated in vitro at high salicylate concentrations (2-...