There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine. Previous data showed that at nanomolar fluxes of peroxynitrite, nitration of these phenolic compounds was outcompeted by dimerization (e.g. biphenols or dityrosi...

Several new analogs of salicylaldehyde isonicotinoyl hydrazone (SIH) and salicylaldehyde benzoyl hydrazone (SBH) that contain an aryl boronic ester (BSIH, BSBH) or acid (BASIH) in place of an aryl hydroxide have been synthesized and characterized as masked metal ion chelators. These pro-chelators show negligible interaction with iron(III), although the boronic acid versions exhibit some interac...

First reports of major defensive chemicals for ground beetles representing four tribes include: Morionini (formic acid), Dercylini (methacrylic and tiglic acids), Catapieseini (formic acid and decyl acetate) and Perigonini (formic acid and decyl acetate). Multiple species from Loxandrini were sampled and, shown to contain formic acid, not salicylaldehyde as previously reported. Several hexenoic...

Tetradentate Schiff bases with a N2O2 donor atom set are well known to coordinate with various metal ions, and this has attracted the interest of many authors1−12. Complexes of Schiff base ligands have been studied for their dioxygen untake and oxidative catalysis. Furthermore, complexes of transition metals(II), which involve derivatives of salicyldhyde and diamine, have received considerable ...

& A PREVIOUS COMMUNICATION (1) we have reported that vanillin reacts with a large number of organic compounds with a carbonyl group, with aldehydes, and particularly with ketones, diketones, and ketonic acids to produce yellowish, or yellowish-red color complexes. Because of its wide reactivity the vanillin-alkali reagent cannot be used for any specific carbonyl compound unless it is first sepa...

The effects of a series of phenolic compounds were compared to the effects of sodium salicylate (2-hydroxybenzoate) on the growth, cell cycle and apoptotic effects in wild-type (WT) and deoxyadenosine-resistant (Y8) L1210 leukemia cells. These compounds included: salicylaldehyde, salicylaldoxime, salicylhydroxamic acid, salicylamide, 5-aminosalicylate and 5-sulfosalicylate. The IC50 values for ...

Four Fe(III) spin-crossover (SCO) compounds, [Fe(HL1)2](HCl4TPA) (1-Cl), [Fe(HL1)2](HBr4TPA) (1-Br), [Fe(HL2)2](HCl4TPA) (2-Cl), and [Fe(HL2)2](HBr4TPA) (2-Br) (HL1 = 4-chloro-2-nitro-6-(1-(2-(pyridine-2-yl)hydrazono)ethyl)phenolate; HL2 = 4-bromo-2-nitro-6-(1-(2(pyridine-2-yl)hydrazono)ethyl)phenolate; HCl4TPA = 2,3,5,6-tetrachloro-4-carboxybenzoate; and HBr4TPA = 2,3,5,6-tetrabromo-4-carboxyb...

Chrysomelid leaf beetles use chemical defenses to overcome predatory attack and microbial infestation. Larvae of Chrysomela lapponica that feed on willow sequester plant-derived salicin and other leaf alcohol glucosides, which are modified in their defensive glands to bioactive compounds. Salicin is converted into salicylaldehyde by a consecutive action of a β-glucosidase and salicyl alcohol ox...

Salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their complexes [Zn(LASSBio-466)H(2)O](2) (1) and [Zn(HLASSBio-1064)Cl](2) (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordin...