The causative mutation for the black-and-tan (a (t) ) phenotype in dogs was previously shown to be a SINE insertion in the 5' region of Agouti Signaling Protein (ASIP). Dogs with the black-and-tan phenotype, as well as dogs with the saddle tan phenotype, genotype as a (t) /_ at this locus. We have identified a 16-bp duplication (g.1875_1890dupCCCCAGGTCAGAGTTT) in an intron of hnRNP associated w...

OBJECTIVE To investigate the possible influences of saddle type on the incidence of "lower back pain" in a cross section of equestrian riders. METHODS 108 equestrian riders completed a questionnaire concerning their riding habits and whether they suffered from lower back pain. In particular they were asked whether they used a traditional style/general purpose saddle (GP) or a deep seated/West...

Hajdu-Cheney syndrome is an autosomal dominant acroosteolysis syndrome, in which clinical and radiological abnormalities develop at different stages of life. A 26-year-old woman visited our rheumatology clinic for progressive shortening of her terminal phalanges. Radiographs showed acro-osteolysis and classic midphalangeal band-like resorption of the terminal phalanges affecting multiple digits...

evidence acquisition initially, we studied two different types of canon and separated all herbs used in the treatment of headache. next, all plants were classified according to the method of prescription. then, we pick out all the plants which were nasally utilized in the treatment of headache and divided them based on the method of administration. in order to find scientific names of herbs, we...

although various techniques have been described for treatment of severe nose deformities, these problems have high revision rates.  conventional nasal septal surgery may not be adequate for all cases. a 21-year-old male patient with nose deformity underwent a nasal surgery. patient had both functional and aesthetic nasal problems. rigid fibular bone graft was used for corrective nasal surgery. ...

Rapid advances in sensor technologies have facilitated the development of high-performance electronic noses that can detect and discriminate volatile compounds in situ. The research and development of electronic noses has resulted in a new qualitative and semi-quantitative detection approach in the field of clinical diagnostics. Electronic noses have a clear potential to be a non-invasive, simp...

To compute the maximum likelihood estimates the log-likelihood function L is maximized with respect to all model parameters. To check that the maximization has been achieved two things have to be satisfied: 1. The vector of first derivatives with respect to the model parameter L′ should be equal to 0. 2. The negative of the matrix of the second derivatives −L′′ should be a positive definite mat...

A saddle point variational (SPV ) method was applied to the Dirac equation as an example of a fully relativistic equation with both negative and positive energy solutions. The effect of the negative energy states was mitigated by maximizing the energy with respect to a relevant parameter while at the same time minimizing it with respect to another parameter in the wave function. The Cornell pot...