The synchronous family of languages (Lustre, Esterel, Signal , Statecharts) provide a great deal of support for verifying a control program at the design and compilation stage. However, a common aspect of embedded systems is that signiicant properties of the system can not be veriied by formally analysing the controller (software) on its own. To analyse the system one requires to state and docu...

Crude dichloromethane and 90%methanolic extracts of plants used traditionally in the treatment of wounds and retained placenta were screened for their antibacterial, anti-inflammatory (cyclooxygenase-1 and-2) activities and investigated for potential mutagenic effects. Antibacterial activity was evaluated using the micro-dilution assay. The bacterial strains used were Staphylococcus aureus (ATC...

Regorafenib is an oral multikinase inhibitor approved for advanced mCRC, gastrointestinal stromal tumors, and hepatocellular carcinoma. The phase 2 regorafenib dose-optimization study (ReDOS; Bekaii-Saab TS, et al., 2019) demonstrated that patients could initiate at a dose of 80 mg/day then subsequently escalate their depending on tolerability without compromising efficacy. In March 2018, the R...

Background: Hepatocellular carcinoma (HCC) is on the rise worldwide. HCC responds poorly to chemotherapy. Lapatinib is an inhibitor of epidermal growth factor receptor and HER2/NEU both implicated in hepatocarcinogenesis. This trial was designed to determine the safety and efficacy of lapatinib in HCC. Methods: A Fleming phase II design with a single stage of 25 patients with a 90% power to exc...

OBJECTIVES Optimising secondary prevention of cardiovascular disease has the greatest potential to reduce recurrent events, yet despite major guidelines there are ongoing treatment gaps. FFSAABC (Fish oils, Fibrates, Statins, Aspirin, Angiotensin converting enzyme inhibitors or angiotensin 2 receptor antagonists, Beta blockers and Clopidogrel) is one mnemonic previously adopted to assist clinic...

This doctoral thesis addresses human resource management in project-based organisations. The aim is to explore the challenges for HRM in project-based organisations and the changes in people management systems to meet these challenges. The thesis consists of a compilation of six papers and an extended summary. The research reported in the thesis is based on a combination of multiple-, comparati...

Evolutionary relationships within the poorly known and anomalous South African endemic genus Lichtensteinia were elucidated. Phylogenetic analysis of morphological and anatomical characters suggests that there are two main groups of species, viz. the L. obscura–L. globosa–L. interrupta (including L. kolbeana) clade and the L. latifolia–L. trifida–L. lacera–L. crassijuga clade. Furthermore, Lich...

METHODS To investigate the influence that psychological workload, associated with simulated combat military flight, has on secretion of stress hormones we measured concentrations of plasma corticotropin-releasing hormone (CRH), pro-opiomelanocortin (POMC) related adrenocorticotropin (ACTH), beta-endorphin (BE), and cortisol in 10 Finnish Air Force (FAF) military interceptor pilots. They perform...

Many recent studies attempting to assess the biochemical connections between anthocyanin biosynthesis and floral scent production have yielded limited insights due in part to a focus on either field phenotypes of unknown genetic background or artificial genetic manipulation. In this study, we seek to more precisely explore the mechanistic connections between floral scent and color in Ipomoea pu...