Applied Physical Chemistry, Department Technology, SE-100 44, Stockholm, Sweden. SP Process Development, Forskargatan, 151 Department of Applied Chemistry, Kumoh Gyeongbuk, Korea † Electronic supplementary information atomic parameters of the structure of th two 2D structures of butyl 1,4-dia 1,8-diammonium lead iodide along th S5–S11 and Fig. S3–S9 describe structura CIF les for the structure...

Eukaryotic ribosomes assemble by association of ribosomal RNA with ribosomal proteins into nuclear precursor particles, which undergo a complex maturation pathway coordinated by non-ribosomal assembly factors. Here, we provide functional insights into how successive structural re-arrangements in ribosomal protein S3 promote maturation of the 40S ribosomal subunit. We show that S3 dimerizes and ...

The understanding of protein-ligand binding is of critical importance for biomedical research, yet the process itself has been very difficult to study because of its intrinsically dynamic character. Here, we have been able to quantitatively reconstruct the complete binding process of the enzyme-inhibitor complex trypsin-benzamidine by performing 495 molecular dynamics simulations of free ligand...

BACKGROUND A physiological third heart sound (S3) is common in youth but allegedly very rare after the age of 40 years. The mechanism of its disappearance is not known. The aim of this work was to study the prevalence and predictors of physiological S3 in a population-based sample of persons approaching 40 years of age. METHODS AND RESULTS A random sample of 120 persons born in 1954 was invit...

The apolipoprotein E (ApoE) gene has been linked to maladies such as hypercholesterolemia, CNS injury and disease. In this study, we present evidence that, in addition to the known transcript (ApoE S1) that translates into ApoE, there are three additional transcripts in mice. Two of these transcripts, ApoE S2 and ApoE S3, which are predicted to be transmembrane proteins, are transcribed from th...

The excessive use of fertilizer has resulted in serious environmental degradation and a high health cost China. Understanding the reasons for overuse is critical to sustainable development Chinese agriculture, large-scale operation considered as one measures deal with use. Under premise fully considering resource endowment heterogeneity farmers small-scale production management, different decis...

We examined how a 50% Pavlovian partial reinforcement (PRF) schedule, versus a 100% continuous reinforcement (CRF) schedule, altered the asymptotic amount and distribution of focal and general search behavior in rats during 48-sec trials with and without a four-segment interfood clock (S1-S2-S3-S4-US). Under CRF, but not PRF, average asymptotic focal search (nosing in the feeder) increased acro...

OBJECTIVES To investigate whether accommodation to depolarising and hyperpolarising currents differs for motor axons of human upper and lower limb nerves. METHODS The threshold tracking technique was used to measure threshold electrotonus for median and peroneal motor axons. The threshold current that produced a compound muscle action potential 50% of maximum was measured, and membrane potent...

The images for S1 Fig, S2 Fig and S3 Fig are swapped. The image for S1 Fig should be S3 Fig, the image for S2 Fig should be S1 Fig, and the image for S3 Fig should be S2 Fig. Please view the correct Supporting Information Figures below. S1 Fig. Stability of fibrinogen and degradation by plasmin. To assess whether degradation of fibrinogen occurs during prolonged incubation at 37°C, purified fib...

Long QT interval syndrome (LQTS) type 1 (LQT1) has been reported to arise from mutations in the S3 domain of KCNQ1, but none of the seven S3 mutations in the literature have been characterized with respect to trafficking or biophysical deficiencies. Surface channel expression was studied using a proteinase K assay for KCNQ1 D202H/N, I204F/M, V205M, S209F, and V215M coexpressed with KCNE1 in mam...