We recently constructed a computable cell proliferation network (CPN) model focused on lung tissue to unravel complex biological processes and their exposure-related perturbations from molecular profiling data. The CPN consists of edges and nodes representing upstream controllers of gene expression largely generated from transcriptomics datasets using Reverse Causal Reasoning (RCR). Here, we re...

Using brain mitochondria isolated from 20-month-old diabetic Goto-Kakizaki rats, we evaluated the efficacy of CoQ10 treatment against mitochondrial dysfunction induced by Abeta1-40. For that purpose, several mitochondrial parameters were evaluated: respiratory indexes (RCR and ADP/O ratio), transmembrane potential (DeltaPsim), repolarization lag phase, repolarization and ATP levels and the capa...

Several applications of continuum regression to non-contaminated data have shown that a significant improvement in predictive power can be obtained compared to the three standard techniques which it encompasses (Ordinary least Squares, Principal Component Regression and Partial Least Squares). For contaminated data continuum regression may yield aberrant estimates due to its non-robustness with...

Mild to moderate glenohumeral osteoarthritis (GHOA) is a common finding among patients who are evaluated for rotator cuff (RC) tears. However, the impact of pre-operative shoulder joint degeneration on patient-reported outcomes (PROs) following RC repair (RCR) not well-established. Certain studies have reported negative association between radiographic findings and RCR PROs, while other found n...

This paper presents the design of RT-Appia, a framework for the development and implementation of configurable real-time protocol stacks. The goal of RT-Appia is to allow the construction of specialized protocols through the composition of pre-defined micro-protocols. RT-Appia attempts to balance the flexibility and efficiency of micro-protocols with the predictability requirements of real-time...

Optimum rehabilitation following Rotator Cuff Repair (RCR) remains a contentious topic. A wide range of often conflicting evidence and opinion exists regarding several aspects the rehabilitation...

Mutagenesis was used to identify and characterize plant genes required for fungal disease resistance gene function in tomato. Seed of a stock homozygous for the Cf-9 gene for resistance to Cladosporium fulvum were treated with ethyl methanesulfonate, and 568 M2 families were screened for mutations to C. fulvum sensitivity. Eight mutants with reduced resistance were isolated. Four mutations, all...

Everyone learns at an early age to pay more attention to what people do than what they say. One of our favorite cartoons is by Edward Argo. It portrays a young child standing in the corner facing the wall and saying to his stuffed animal friend, " The same people who told me the stork brought me are making me stand here for lying. " You can substitute your own favorite example of the discrepanc...

This paper describes the design of a new rate and congestion controller (RCR) which employs FEC (forward error correction) support. The design follows the design principles of TCP but uses FEC to assure TCP-competitiveness. It is targeted primarily at one to many reliable bulk multicast data transfer. It shares bandwidth with other TCP flows fairly and is able to compensate drawbacks due to low...