BACKGROUND A recently developed probe-based technology, the NanoString nCounter™ gene expression system, has been shown to allow accurate mRNA transcript quantification using low amounts of total RNA. We assessed the ability of this technology for mRNA expression quantification in archived formalin-fixed, paraffin-embedded (FFPE) oral carcinoma samples. RESULTS We measured the mRNA transcript...

UNLABELLED 18F-fluoroethyl-SPA-RQ (18F-FE-SPA-RQ) was recently developed as a radioligand for the measurement of neurokinin 1 (NK1) receptor with PET. In this study, we used 18F-FE-SPA-RQ with PET to visualize and quantify NK1 receptor in the human brain. METHODS PET scans were performed on 7 healthy men after intravenous injection of 18F-FE-SPA-RQ. Binding potential (BPND) was calculated by ...

Environmental risk assessment of pesticides and other chemicals often uses the Risk Quotient (RQ) method to characterize risk quantitatively. An RQ is calculated by dividing an environmental exposure value by a toxicity end-point value. Tier 1 RQs, which are characterized by highly conservative toxicity and exposure assumptions, are used primarily for screening out negligible risks in regulator...

Heart rate, Blood Pressure and Rate pressure product are important physiological parameters that can be utilized to analyze the physical condition of the human body. However, the step-by-step analysis on the changes of ECG waveforms and RPP before and after regular exercise has been presenting in this paper. This proposed work examines the Changes of ECG waveforms after regular exercise. Rate p...

BACKGROUND Numerous genetic studies revealed several susceptibility genes of autoimmune thyroid diseases (AITD), including CTLA4, PTPN22 and FCRL3. These immune-modulating genes are involved in genetic background of AITD among children and adult patients. However, possible age-related differences in overexpression of these genes remain unclear. PURPOSE The goal of this single centre cohort st...

Isolated human populations represent good candidates for studying genetic and environmental causes of common complex diseases because of their decreased genetic and environmental diversity. The possibility of inexpensive and reliable detection of disease prevalence in such populations is therefore of considerable importance, as comprehensive routine health data and disease registries are rarely...

The respiratory gaseous exchanges of detached whole mangrove seedlings (Avicennia, Bruguiera, Rhizophora) in a range of O(2) concentrations from 0 to 21% (air) were markedly reduced by the presence of external CO(2). Aerobic respiration decreased steadily for 16 days but the RQ remained at unity.In anoxia CO(2) output fell to half that in air. Ethanol accumulation was negligible but, relatively...

Davidson, Alec J., and Friedrich K. Stephan. Feedingentrained circadian rhythms in hypophysectomized rats with suprachiasmatic nucleus lesions. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1376–R1384, 1999.— Several pituitary hormones are important in the regulation of metabolism, and their release appears to be controlled by a circadian clock. Consequently, they may be invo...

Copy Number Variation has been associated with morphological traits, developmental defects or disease susceptibility. The autosomal dominant Pea-comb mutation in chickens is due to the massive amplification of a CNV in intron 1 of SOX5 and provides a unique opportunity to assess the effect of variation in the number of repeats on quantitative traits such as comb size and comb mass in Pea-comb c...