r M ' R I N G the earlier few months of the first World War, play fell off. But after Ihe public was sold—and sold itself —on the idea that keeping fit was part of the job of winning Ihe war, play was resumed on possibly a greater schedule than previously. I n those days there was very l i t t le play by shop and office workers , but the business executive class wh ich was p l ay i ng g o l f h...

Transcription factor GATA-2 is implicated in the survival and growth of multipotential progenitors. Here we report that the promyelocytic leukemia zinc finger (PLZF) protein can interact with GATA-2 and can modify its transactivation capacity. Fanconi anemia zinc finger (FAZF), a PLZF-homologous protein that has been variously described as ROG (repressor of GATA), and TZFP (testis zinc finger p...

I N T R O D U C T I O N This paper presents data which correlate l ight-dependent changes in cyclic GMP with the in vitro physiology of f rog retinal rod outer segments. Two papers previously presented in this journa l provide background for the experiments presented here. The first described the development of an assay for observing outer segment function in vitro (1); the second demonst ra te...

This study is aimed to review the stress management techniques adopted by Indian Air Force for Airmen and Senior non-commissioned officers (SNCO) i.e. person below officer rank (PBOR) based on the recommendation of 31 st parliamentary standing committee on Indian Defence Forces in 2008. The comments were taken from both peace and field station. Research technique used was questionnaire. 60 serv...

Following lymphocyte depletion, homeostatic mechanisms drive the reconstitution of lymphocytes. We prospectively studied this process in 16 patients for 1 year after a single pulse of treatment with Campath-1H, a humanised anti-CD52 monoclonal antibody. We observed two phases of lymphocyte reconstitution. In the first 6 months after treatment the precursor frequency and proliferation index of t...

The PLZF (promyelocytic leukemia zinc finger) transcriptional repressor, when fused to retinoic acid receptor alpha (RARalpha), causes a refractory form of acute promyelocytic leukemia. The highly conserved N-terminal BTB (bric a brac, tramtrack, broad complex)/POZ domain of PLZF plays a critical role in this disease, since it is required for transcriptional repression by the PLZF-RARalpha fusi...

The components of receptor tyrosine kinase signaling complexes help to define the specificity of the effects of their activation. The Caenorhabditis elegans fibroblast growth factor receptor (FGFR), EGL-15, regulates a number of processes, including sex myoblast (SM) migration guidance and fluid homeostasis, both of which require a Grb2/Sos/Ras cassette of signaling components. Here we show tha...