OBJECTIVE To evaluate the biochemical changes associated with succinylcholine administration after pretreatment with rocuronium at different time intervals. METHOD The prospective, randomised, single-blinded study was conducted at the Combined Military Hospital, Rawalpindi, from January to May 2010. Ninety male, aged 18-60 years, American Society of Anaesthesiology I or II patients undergoing...

Brunaud and Fuchs-Buder wrote a letter in response to our recent study to bring the selective sugammadex reversal approach for neural monitoring to the attention of readers. They stated that the need for sugammadex to restore neuromuscular function allowing adequate intraoperative neuromonitoring (IONM) is rather infrequent and observed in less than approximately 20% of patients. Consequently, ...

Sugammadex is a revolutionary investigational reversal drug currently undergoing Phase III testing whose introduction into clinical practice may change the face of clinical neuromuscular pharmacology. A modified gamma-cyclodextrin, sugammadex exerts its effect by forming very tight water-soluble complexes at a 1:1 ratio with steroidal neuromuscular blocking drugs (rocuronium > vecuronium >> pan...

BACKGROUND Binding of the steroidal molecule of rocuronium by a cyclodextrin is a new concept for reversal of neuromuscular block. The present study evaluated the ability of Sugammadex Org 25969, a synthetic gamma-cyclodextrin derivative, to reverse constant neuromuscular block of about 90% induced by rocuronium or the non-steroidal neuromuscular blocking drugs, mivacurium or atracurium, in the...

STUDY OBJECTIVE To test whether rapid injection of rocuronium reduces withdrawal movement on injection. DESIGN Randomized, prospective trial. SETTING Operating room in a university hospital. PATIENTS 150 ASA physical status I and II patients aged 18 to 60 years, undergoing general anesthesia. INTERVENTIONS Patients were randomized to three groups. After undergoing anesthesia induction w...

BACKGROUND Partially paralyzed patients may be placed in the risk of pharyngeal dysfunction. Bupivacaine acts as acetylcholine receptor ion channel blocker and may synergistically interact with rocuronium to augment NM blockade. Thus, this study aims to elucidate whether or not, at a therapeutic concentration, bupivacaine by itself may cause NM blockade and reduce an effective concentration of ...

BACKGROUND An unanticipated difficult airway may arise during rapid sequence induction and intubation (RSII). The aim of the trial was to assess how rapidly spontaneous ventilation could be re-established after RSII. We hypothesized that the time period from tracheal intubation to spontaneous ventilation would be shorter with rocuronium-sugammadex than with succinylcholine. METHODS This rando...

2 mg h were given. Sugammadex 400 mg was also given, bringing the total to 16 mg kg. Again arterial pressure increased to 140/65 mm Hg and stabilized, the heart rate decreased to 90 beats min, and the bronchospasm relaxed. The operation was postponed. Methyprednisolone 100 mg was given and she was weaned off the epinephrine infusion over the next 10 h. Analysis of the blood samples supported a ...

Background: The incidence of unanticipated difficult airways is higher in pediatric age groups than adults due to the different airway anatomy, difficulty examination, and congenital malformations. Rocuronium bromide has a comparable onset time succinylcholine at its proportionate dose. Hence, we compared rocuronium with assess intubating conditions their side effects, if any. Method: A total 2...

BACKGROUND The main disadvantage of rocuronium is the pain associated with vascular injection. We evaluated the efficacy of palonosetron for reducing pain after rocuronium injection. METHODS EIGHTY PATIENTS SCHEDULED FOR ELECTIVE SURGERY WERE RANDOMLY DIVIDED INTO TWO GROUPS: Group C (normal saline 1.5 ml, n = 40) and Group P (palonosetron 0.075 mg, n = 40). Anesthesia was induced with thiope...