The present study was designed to compare the effects of typical and atypical antipsychotic drugs on extracellular dopamine (DA) levels in the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAC), using in vivo microdialysis with dual probe implantation in awake, freely moving rats. Amperozide (2 and 10 mg/kg), clozapine (5 and 20 mg/kg), and olanzapine (10 mg/kg), all of which are a...

Ro 63–0563 [4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)benzene sulfonamide] is a high affinity 5-hydroxytryptamine6 (HT6) receptor antagonist with more than 100-fold selectivity for the 5-HT6 receptor compared with 69 other receptors and binding sites. The present study describes the properties of [H]Ro 63–0563, the first selective 5-HT6 receptor radioligand. Specific binding of [H]Ro 63–0563 ...

EditorÐWe congratulate the authors on an excellent review of aspects of the pathophysiology of malignant hyperthermia (MH). They have explained the postulated role of serotonin in MH, in particular the role of peripheral 5-HT2 receptors, based on in vitro and in vivo animal work. There are important parallels between serotonin toxicity and MH, and this review adds to our understanding of the ro...

The characterization and anatomical distribution of 5-hydroxytryptamine (5-HT)7 receptor binding sites in brain tissue has been hampered by the lack of a specific radioligand. In the present autoradiographic study, we took advantage of 5-HT1A knockout and 5-HT1A/1B double-knockout mice to revisit the pharmacological characterization and anatomical localization of 5-HT7 binding sites in mouse br...