نتایج جستجو برای: ring opeing of epoxides
تعداد نتایج: 21176018 فیلتر نتایج به سال:
The mutagenic activities of benz(a)acridine, benz(c)acridine, and a number of their derivatives, including 12 epoxides and diol-epoxides, were examined in bacterial and mammalian cells to determine the importance of bay-region activation of azapolycyclic aromatic hydrocarbons. In Salmonella typhimurium strain TA98, the diastereomeric bay-region 3,4-diol-1,2-epoxides of benz(c)acridine, in which...
nogenic activity (4). Chrysene, which has one more benzene ring than does phenanthrene, is a symmetrical molecule with 2 identical bay regions (Chart 1). Chrysene has weak activity in carcinogenicity tests (4, 11). Quantum mechanical aspects of the bay region theory predict (6) that bay-region 1,2-diol 3,4-epoxides of chrysene and phenanthrene should have sim ilar chemical reactivities. Kinetic...
A mass spectrometric method has been delineated for the identification of the epoxide functionalities in unknown monofunctional analytes. This method utilizes gas-phase ion/molecule reactions of protonated analytes with neutral trimethyl borate (TMB) followed by collision-activated dissociation (CAD) in an ion trapping mass spectrometer (tested for a Fourier-transform ion cyclotron resonance an...
A strategy for the creation of sp 3 -rich, non-planar scaffolds drug discovery is described. Stereocontrolled ring opening homochiral 1,2-epoxides by hydrazine monohydrate followed selective protection both nitrogen atoms and Mitsunobu closure gives differentially protected, enantiomerically pure 1,2-diazetidines (up to 98% ee) bearing a variety C-3 substituents. Iterative C–N functionalization...
Covalent double functionalization of graphene oxide for proton conductive and redox-active functions
The covalent double functionalization of graphene oxide (GO) is an effective approach to tune the properties graphene-like materials. first step ring-opening reaction epoxides by amines, followed second consisting on nucleophilic addition GO hydroxyl groups ?,?-unsaturated carbonyl compound. benefit doubly functionalized possess different functions, confirmed measuring proton conductivity and s...
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