A19-year-old woman with mild exercise intolerance was referred for follow-up examination of a known ventricular septal defect (VSD; Figure 1A). By continuous-wave Doppler, a gradient across the tricuspid valve of 60 mm Hg was recorded. The parasternal short-axis view revealed an anomalous muscle bundle with insertion at the interventricular septum and the right ventricular (RV) free wall (Figur...

A 47-year-old patient visited our outpatient clinic. She was born with tricuspid atresia with normally connected great arteries without pulmonary stenosis (type Ic); a ventricular septal defect connected the pulmonary artery and hypoplastic right ventricle (RV) with the left ventricle. When she was 14 years old, a Fontan-Bjork procedure was performed.1 The atrial and the ventricular septal defe...

Measurements of right coronary artery blood flow, aortic and right ventricular (RV) pressures and heart rate were radiotelemetered during strenuous, spontaneous exercise in normal dogs and dogs with severe RV hypertrophy induced by chronic (5-6 mo) pulmonary artery stenosis. With fixed pulmonic stenosis, dogs with RV hypertrophy exhibited a decrease (P less than 0.01) in arterial pressure durin...

BACKGROUND Myostatin is a negative regulator of skeletal muscle mass whose activity is upregulated in adult heart failure (HF); however, its role in congenital heart disease (CHD) is unknown. METHODS We studied myostatin and IGF-1 expression via Western blot in cardiac tissue at varying degrees of myocardial dysfunction and after biventricular support in CHD by collecting myocardial biopsies ...

 Abstract Background: Right ventricular myocardial performance index (RVMPI) is a Doppler–derived parameter of non-geometrical ventricular function that measures both systolic and diastolic functions of the right ventricle. The aim of this study is to compare prognostic value of RVMPI with global RV function in patients undergoing Coronary Artery Bypass Graft (CABG). Methods: In a longitudinal ...

Septation is one of the surgical choices for double-inlet left ventricle, yet postoperative hemodynamics have not been well defined. We studied ventricular volume characteristics in 10 patients with double-inlet left ventricle before and after septation. Preoperative end-diastolic volume (EDV) of the ventricle was 291±111% (±SD) of normal and ejection fraction (EF) was 0.59± 0.07. Postoperative...

This study investigated Ca2+ -cycling properties of sarcoplasmic reticulum (SR) in right ventricle (RV) and left ventricle (LV) of normal rat myocardium. Intracellular Ca2+ transients and contractile function were monitored in freshly isolated myocytes from RV and LV. SR in RV displayed nearly fourfold lower rates of ATP-energized Ca2+ uptake in vitro than SR of LV. The Ca2+ concentration requi...

Right ventricular (RV) dysfunction can serve as an indicator of heart and lung disease and can adversely affect the left ventricle. However, normal RV function must be characterized before abnormal states can be detected. We describe a method for reconstructing the 3D motion of the RV by fitting a deformable model to tag and contour data extracted from multiview tagged magnetic resonance images...

Although early surgical repair for tetralogy of Fallot (rTOF) has significantly improved clinical outcomes and long-term survival, progressive right ventricle (RV) dysfunction driving morbidity and mortality is often observed in adults with rTOF. Management of RV heart failure is occasionally refractory to even appropriate medical therapies. RV mechanical dyssynchrony that is commonly observed ...

We report a case of right ventricular (RV) diastolic dysfunction due to a large hematoma posterior to the left ventricle (LV) after cardiac surgery. An 80-year-old woman underwent cardiac surgery. After surgery, her physical findings revealed right heart failure. Localized hematoma posterior to the pericardial space and the RV compression to the sternum were shown by computed tomography. Transt...