STUDY OBJECTIVE Previous studies have suggested that aggressive treatment of sinusitis can decrease bronchial hyperresponsiveness (BHR). However, there is still too little evidence to draw this conclusion, and the concept remains controversial. DESIGN A prospective, open-label study. SETTING University children's hospital allergy and immunology center and radiologic department. PATIENTS S...

The rhino mouse, a single gene recessive mutation, is characterized by abnormal epidermal differentiation and maturation leading to the loss of hair at 1 month of age as well as follicular and epidermal hyperkeratoses. We evaluated the lids and corneas of nine rhino mice and their normal litter mates at various ages from 3 months to 1 year. Tissue specimens were studied by light microscopy, sca...

Computerised tomography (CT) scan imaging techniques acts as a guide for functional endoscopic sinus surgery (FESS). It plays a vital role in the successful outcome of the treatment and management of the paranasal sinus variations. The frequent predisposing factors of chronic sinusitis are the anatomical variations of the paranasal sinus and nasal region. Computed tomography (CT) scan plays a f...

Each year, around 2% of the UK population consults their GP about a suspected sinus infection (Ashworth 2005). Most people with acute sinusitis recover with or without treatment within 10 days of seeing a GP (Williamson 2007), but about 92% are prescribed an antibacterial, even though it makes little difference to outcome. (Ashworth 2005) Acute sinusitis is defined as inflammation of the nose a...

Chronic sinusitis is a common disease that encompasses a number of syndromes that are characterized by sinonasal mucosal inflammation. Chronic sinusitis can be defined as two or more of the following symptoms lasting for more than 12 consecutive weeks: discolored rhinorrhea, postnasal drip, nasal obstruction, facial pressure or pain, or decreased sense of smell. Chronic sinusitis is further cla...

health care impact. This review focuses on factors contributing to sinusitis pathogenesis and chronicity, including anatomic factors, disturbances in mucociliary clearance, microbial pathogens, and inflammatory factors. A distinction is made between “infectious” and “noninfectious” types of inflammation in chronic sinusitis. The inflammatory characteristics of noninfectious inflammation are rev...

Introduction Percutaneous tracheostomy is one of the most commonly operative procedures performed in Intensive Care Unit (ICU) patients [1]. Ciaglia Blue Rhino technique (CBR) is used in our ICU. In our clinical practice we sometimes encountered difficulties in doing initial dilatation of the soft tissue and tracheal wall with the Blue Rhino dilator: it occurs expecially in young or obese patie...

Piwi-interacting RNAs (piRNAs) silence transposons and maintain genome integrity during germline development. In Drosophila, transposon-rich heterochromatic clusters encode piRNAs either on both genomic strands (dual-strand clusters) or predominantly one genomic strand (uni-strand clusters). Primary piRNAs derived from these clusters are proposed to drive a ping-pong amplification cycle catalyz...